D3 RECEPTOR AGONIST COMPOUNDS; METHODS OF PREPARATION; INTERMEDIATES THEREOF; AND METHODS OF USE THEREOF
Disclosed herein are novel compounds including dopamine D3 receptor agonists, compositions thereof, methods of use thereof, and processes of synthesizing the same. Further disclosed are D3R selective agonist compounds, specifically bitopic ligands comprising chirality.
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Paragraph 0168; 0172
(2020/10/21)
Facile synthesis of 2-azaspiro[3.4]octane
Our annulation strategy utilized for the synthesis of 2-azaspiro[3.4]octane is explained. Three successful routes for the synthesis were developed. One of the approaches involved annulation of the cyclopentane ring and the remaining two approaches involved annulation of the four membered ring. All three approaches employ readily available starting materials with conventional chemical transformations and minimal chromatographic purifications to afford the title compound. The merits and limitations of the three approaches are also discussed.
Ramesh, Subbiah,Balakumar, Ramadas,Rizzo, John R.,Zhang, Tony Y.
p. 3056 - 3065
(2019/03/21)
Samarium diiodide-mediated pinacolization of diketones - II. Synthesis of polycyclic frameworks containing a cyclobutane-1,2-diol and a cyclopentane-1,2-diol
The title reaction has been applied to the synthesis of a variety of polycyclic networks. Scope and limitations of the procedure are evaluated.
General theoretical treatments of solid-state photochemical rearrangements and a variety of contrasting crystal versus solution photochemistry
In continuing our investigations of control of excited state reactivity by inclusion in crystal lattices, we have encountered a variety of new examples of differing reactivity resulting from lattice restraints. Different theoretical treatments were tested
Zimmerman, Howard E.,Zhu, Zhaoning
p. 5245 - 5262
(2007/10/02)
Synthesis of bridgehead-substituted bicyclo[2.2.1]heptanes. Radical cyclization of an oxime ether and an α,β-unsaturated ester
The synthesis of bicyclo[2.2.1]heptanes with useful functionality at each bridgehead is achieved by radical cyclization of appropriately substituted 4-methylene- and 4-benzyloxyiminocyclohexylmethyl radicals. The latter process, for example, leads to a br
Della,Knill
p. 1833 - 1841
(2007/10/02)
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