- NOVEL CHROMOPHORIC SILYL PROTECTING GROUPS AND THEIR USE IN THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES
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The present invention provides compounds of the formula (I): C-Q-O-Si (R1)(R2)-N wherein C is a chromophore; Q is selected from the group consisting of optionally substituted aliphatic, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R1 and R2 are independently selected from the group consisting of optionally substituted C1-8 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-8 alkyloxy, cycloalkyloxy, heterocycloalkyloxy, alkylsilyloxy and arylsilyloxy; and N is a glycosylamine or abasic moiety.
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Page/Page column 30; 41
(2009/01/20)
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- Oligoribonucleotide and ribozyme analogs with terminal 3′—3′ and/or 5′—5′ linkages
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The invention relates to oligoribonucleotide analogs with terminal 3′—3′ and/or 5′—5′ internucleotide linkages. This modification stabilizes the molecules altered in this way, including ribozymes, without adversely altering their properties, including, where appropriate, catalytic activities.
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