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N4-Acetyl-2'-Fluoro-2'-deoxycytidine is a nucleoside analog with potential antineoplastic activity. It is an acetylated fluoro-derivative of the nucleoside cytidine, designed to inhibit DNA synthesis and repair. This chemical potentially replaces cytidine in RNA during transcription and interferes with enzymes involved in DNA replication, leading to the inhibition of tumor cell growth.

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    Cas No: 159414-97-8

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  • 159414-97-8 Structure
  • Basic information

    1. Product Name: N4-Acetyl-2'-Fluoro-2'-deoxycytidine
    2. Synonyms: N4-Acetyl-2'-Fluoro-2'-deoxycytidine;Ac-2'-F-dC;N4-Acetyl-2'-deoxy-2'-fluorocytidine;Cytidine, N-acetyl-2'-deoxy-2'-fluoro-
    3. CAS NO:159414-97-8
    4. Molecular Formula: C11H14FN3O5
    5. Molecular Weight: 287.2443632
    6. EINECS: 1312995-182-4
    7. Product Categories: N/A
    8. Mol File: 159414-97-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.68±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 10.13±0.20(Predicted)
    10. CAS DataBase Reference: N4-Acetyl-2'-Fluoro-2'-deoxycytidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N4-Acetyl-2'-Fluoro-2'-deoxycytidine(159414-97-8)
    12. EPA Substance Registry System: N4-Acetyl-2'-Fluoro-2'-deoxycytidine(159414-97-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 159414-97-8(Hazardous Substances Data)

159414-97-8 Usage

Uses

Used in Oncology:
N4-Acetyl-2'-Fluoro-2'-deoxycytidine is used as an antineoplastic agent for its potential in treating various types of cancer. It is particularly effective against solid tumors and hematologic malignancies due to its ability to inhibit DNA synthesis and repair, thereby disrupting tumor cell growth.
Used in Cancer Research:
In the field of cancer research, N4-Acetyl-2'-Fluoro-2'-deoxycytidine is utilized for its potential to replace cytidine in RNA during transcription and interfere with enzymes involved in DNA replication. This makes it a valuable tool for studying the mechanisms of tumor growth and identifying new therapeutic targets.
Used in Drug Development:
N4-Acetyl-2'-Fluoro-2'-deoxycytidine is being investigated for its potential use in the development of new cancer treatments. Its unique properties as a nucleoside analog and its ability to inhibit DNA synthesis and repair make it a promising candidate for further research and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 159414-97-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,4,1 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 159414-97:
(8*1)+(7*5)+(6*9)+(5*4)+(4*1)+(3*4)+(2*9)+(1*7)=158
158 % 10 = 8
So 159414-97-8 is a valid CAS Registry Number.

159414-97-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

1.2 Other means of identification

Product number -
Other names N4-Acetyl-2'-deoxy-2'-fluorocytidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:159414-97-8 SDS

159414-97-8Downstream Products

159414-97-8Relevant articles and documents

NOVEL CHROMOPHORIC SILYL PROTECTING GROUPS AND THEIR USE IN THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES

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Page/Page column 30; 41, (2009/01/20)

The present invention provides compounds of the formula (I): C-Q-O-Si (R1)(R2)-N wherein C is a chromophore; Q is selected from the group consisting of optionally substituted aliphatic, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R1 and R2 are independently selected from the group consisting of optionally substituted C1-8 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-8 alkyloxy, cycloalkyloxy, heterocycloalkyloxy, alkylsilyloxy and arylsilyloxy; and N is a glycosylamine or abasic moiety.

Oligoribonucleotide and ribozyme analogs with terminal 3′—3′ and/or 5′—5′ linkages

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, (2008/06/13)

The invention relates to oligoribonucleotide analogs with terminal 3′—3′ and/or 5′—5′ internucleotide linkages. This modification stabilizes the molecules altered in this way, including ribozymes, without adversely altering their properties, including, where appropriate, catalytic activities.

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