N4-Acetyl-2'-Fluoro-2'-deoxycytidine

Base Information

• Chemical Name: N4-Acetyl-2'-Fluoro-2'-deoxycytidine
• CAS No.: 159414-97-8
• Molecular Formula: C11H14FN3O5
• Molecular Weight: 287.24
• Hs Code.: 2934999090
• Mol file: 159414-97-8.mol

Synonyms:N4-Acetyl-2'-Fluoro-2'-deoxycytidine;Ac-2'-F-dC;N4-Acetyl-2'-deoxy-2'-fluorocytidine;Cytidine, N-acetyl-2'-deoxy-2'-fluoro-

Chemical Property of N4-Acetyl-2'-Fluoro-2'-deoxycytidine

Chemical Property:

• PKA: 10.13±0.20(Predicted)
• PSA: 117.17000
• Density: 1.68±0.1 g/cm3(Predicted)
• LogP: -0.56010

Purity/Quality:

98%, ^*data from raw suppliers

N4-Acetyl-2’-deoxy-2’-fluorocytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N4-Acetyl-2'-Fluoro-2'-deoxycytidine

There total 2 articles about N4-Acetyl-2'-Fluoro-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2'-fluoro-2'-deoxycytidine hydrochloride → 4-N-acetyl-2'-fluoro-2'-deoxycytidine (159414-97-8)

Guidance literature:

With pyridine; acetic anhydride; triethylamine; In methanol; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

acetic anhydride (108-24-7) + 2'-deoxy-2'-fluorocytidine (10212-20-1) → 4-N-acetyl-2'-fluoro-2'-deoxycytidine (159414-97-8)

Guidance literature:

In ethanol; at 70 ℃; for 3h;

upstream raw materials:

acetic anhydride

2'-deoxy-2'-fluorocytidine

Refernces

• 1、 -. "Oligoribonucleotide and ribozyme analogs with terminal 3′—3′ and/or 5′—5′ linkages". . . Retrieved 2008/06/13.