159610-93-2

Basic information

• Product Name: FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID
• Synonyms: N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-SERINE;FMOC-L-SER(ME)-OH;FMOC-O-METHYL-L-SER;FMOC-(S)-2-AMINO-3-METHOXYLPROPANOIC ACID;FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID;FMoc-Ser(Me)-OH;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-serine;(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser(Me)-OH
• CAS NO: 159610-93-2
• Molecular Formula: C₁₉H₁₉NO₅
• Molecular Weight: 341.36
• Product Categories: unnatural amino acids
• Mol File: 159610-93-2.mol

Chemical Properties

• Boiling Point: 567.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.285±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID(159610-93-2)
• EPA Substance Registry System: FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID(159610-93-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 159610-93-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID is used as a key intermediate in the synthesis of peptide-based drugs for its ability to facilitate the formation of complex peptide structures. Its role in protecting the amine group during synthesis ensures the integrity and functionality of the final drug product.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID is used as a building block for the development of novel therapeutic agents. Its unique properties allow researchers to explore new avenues in drug design and the creation of compounds with specific biological activities.
Used in Peptide Synthesis:
FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID is used as a protecting group in solid-phase peptide synthesis to shield the amine group of amino acids. This protection is vital for preventing unwanted side reactions during the assembly of peptide chains, thereby enhancing the yield and purity of the final peptide product.
Used in Drug Discovery:
FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID is utilized in drug discovery processes to create and investigate peptide-protein interactions. Understanding these interactions is crucial for identifying potential drug targets and developing new therapeutic strategies to combat various diseases.
Overall, FMOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID is a versatile and essential compound in the fields of pharmaceuticals, medicinal chemistry, and drug discovery, playing a pivotal role in the advancement of peptide-based therapeutics and our understanding of biological systems.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 4219-94-7 DL-3-methoxy-alanine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant articles and documents

Kras inhibitory cyclic peptide compound

The following were discovered: a cyclic peptide compound that interacts with Ras; and an unnatural amino acid that is useful in the production of said cyclic peptide compound. The cyclic peptide compound was also discovered to inhibit bonding between Ras and SOS. The following were additionally discovered: a specific unnatural amino acid included in said cyclic peptide compound; and a manufacturing method therefor.

Compounds for enzyme inhibition

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide