159652-30-9

Basic information

• Product Name: BOC-D-DAP(BOC)-OH DCHA
• Synonyms: BOC-D-DAP(BOC)-OH DCHA;N-ALPHA,N-BETA-DI-BOC-D-2,3-DIAMINOPROPIONIC ACID DICYCLOHEXYLAMINE SALT;N2,N3-DI-BOC-D-2,3-DIAMINOPROPIONIC ACID DICYCLOHEXYLAMINE SALT;N-Boc-3-(Boc-amino)-D-alanine
• CAS NO: 159652-30-9
• Molecular Formula: C₁₃H₂₄N₂O₆
• Molecular Weight: 485.66
• Mol File: 159652-30-9.mol

Chemical Properties

• Boiling Point: 469.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.157±0.06 g/cm3(Predicted)
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: BOC-D-DAP(BOC)-OH DCHA(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-DAP(BOC)-OH DCHA(159652-30-9)
• EPA Substance Registry System: BOC-D-DAP(BOC)-OH DCHA(159652-30-9)

Safety Data

• Hazardous Substances Data: 159652-30-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1482-97-9 (2R)-2,3-diaminopropanoic acid monohydrochloride 
• 259825-43-9 (R)-2-amino-3-((tert-butoxycarbonyl)amino)propanoic acid 
• 515-94-6 D-DAP 
• 73259-81-1 (R)-2-tert-butoxycarbonyl-3-aminopropionic acid 
• 7536-55-2 N-t-butyloxycarbonyl-D-asparagine 
• 541-16-2 t-butyl malonate 

Downstream Products

• 1429555-68-9 C₂₃H₄₂N₄O₅ 
• 1429555-43-0 C₂₃H₃₆N₄O₅ 
• 1426408-65-2 {(R)-2-tert-butoxycarbonylamino-2-[1-phenyl-5-(3-propylphenyl)-1H-pyrazol-3-ylcarbamoyl]-ethyl}carbamic acid tert-butyl ester 

Relevant articles and documents

COMPOUNDS THAT TRAP ALPHA-OXOALDEHYDES AND ALPHA-BETA-UNSATURATED ALDEHYDES, META-COMPOUNDS CONTAINING SUCH COMPOUNDS, AND USE OF SAID COMPOUNDS IN TREATING ILLNESSES RELATED TO THE ACCUMULATION OF AGES AND ALES

The present invention relates to a series of molecules derived from 2,3-diaminopropionic acid (DAP), comprising or not comprising an 8-hydroxyquinoline (8-HQ) motif, and to the use of said molecules for trapping an alpha-oxoaldehyde resulting particularly from the degradation of the glucose or for trapping an alpha-beta-unsaturated aldehyde, resulting particularly from the oxidative degradation of fatty acids. These molecules can have a further application in the fields of cosmetics, food processing, and pharmaceuticals.

PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF

The present invention provides a pyrazole compound of the following general Formula [1b] having SGLT1 inhibitory activity, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and its pharmaceutical use wherein each symbol is the same as defined in the description

New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation

Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde. The Royal Society of Chemistry 2013.

Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides

The N-termini of bacterial lipoproteins are acylated with a (S)-(2,3-bisacyloxypropyl)cysteinyl residue. Lipopeptides derived from lipoproteins activate innate immune responses by engaging Toll-like receptor 2 (TLR2) and are highly immunostimulatory and yet without apparent toxicity in animal models. The lipopeptides may therefore be useful as potential immunotherapeutic agents. Previous structure-activity relationships in such lipopeptides have largely been obtained using murine cells, and it is now clear that significant species-specific differences exist between human and murine TLR responses. We have examined in detail the role of the highly conserved Cys residue as well as the geometry and stereochemistry of the Cys-Ser dipeptide unit. (R)-Diacylthioglycerol analogues are maximally active in reporter gene assays using human TLR2. The Cys-Ser dipeptide unit represents the minimal part-structure, but its stereochemistry was found not to be a critical determinant of activity. The thioether bridge between the diacyl and dipeptide units is crucial, and replacement by an oxoether bridge results in a dramatic decrease in activity.