The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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Page/Page column 40; 41
(2009/09/08)
Parallel-stranded oligonucleotide duplexes containing 5- methylisocytosine-guanine and isoguanine-cytosine base pairs
Parallel-stranded oligonucleotides containing 5-methylisocytosine- guanine and/or isoguanine-cytosine base pairs were prepared. The coupling efficiency was higher than 99% when the phosphoramidites of 2'-deoxy-5- methylisocytidine (2a) and of 2'-deoxyisoguanosine (3) were employed in solid-phase synthesis. The glycosylic bond of 2'-deoxy-5-methylisocytidine (1a) is stabilized against acid in the case of the amidine derivatives 4a, b. Depyrimidination occurs upon extended exposure to ammonia. The orientation of the parallel-stranded (ps) duplexes was unambiguously determined using the pyrene excimer fluorescence. The antiparallel (aps) duplex d(A12)·d(T12) (25.26) turned into the parallel orientation when two central adenine- thymine base pairs were replaced by isoguanine-cytosine pairs. The thermal stability of ps-duplexes containing 5-methylisocytosine-guanine base pairs was found to be significantly lower than that of duplexes with isoguanine, cytosine pairs. According to the CD spectra, ps-DNA-DNA or DNA-RNA hybrids show differences in their secondary structures compared to their aps counterparts.
Seela, Frank,He, Yang,Wei, Changfu
p. 9481 - 9500
(2007/10/03)
NOVEL RING TRANSFORMATION REACTIONS AND THEIR APPLICATIONS TO THE SYNTHESES OF POTENTIAL ANTICANCER HETEROCYCLIC COMPOUNDS
Novel heterocyclic ring trasformation reactions developed recently in our laboratory are described.They include pyrimidine to pyrimidine, pyrimidine to pyridine transformations.Also discussed are novel one-step procedures for conversion of 1,3-dimethyluracil derivatives into the pyridopyrimidine system.Some applications of these novel reactions to the syntheses of compounds of biological interest are also described.
Watanabe, K. A.,Su, T.-L.,Pankiewicz, K. W.,Harada, K.
p. 289 - 307
(2007/10/02)
Alkylated pyrimidine derivatives as antiviral agents. I. Syntheses and antiviral screening of alkylpyrimidine and 5-alkyluracil nucleoside.
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Muraoka,Takada,Ueda
p. 261 - 268
(2007/10/04)
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