15981-91-6

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-amino-5-methyl- (7CI,8CI,9CI)
• Synonyms: 4(1H)-Pyrimidinone, 2-amino-5-methyl- (7CI,8CI,9CI);4(1H)-Pyrimidinone, 2-amino-5-methyl- (8ci)(9ci);Nsc 60208;2-amino-5-methyl-4-pyrimidinol(SALTDATA: FREE);2-amino-5-methyl-4-pyrimidinol;2-amino-5-methylpyrimidin-4(1H)-one;2-Amino-5-methyl-1H-pyrimidin-4-one;2-Amino-5-methylpyrimidin-4(3H)-one
• CAS NO: 15981-91-6
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.12858
• Product Categories: PYRIMIDINE
• Mol File: 15981-91-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 277-279 °C
• Appearance: /
• Density: 1.44 g/cm³
• Refractive Index: 1.651
• PKA: 9.74±0.50(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-amino-5-methyl- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-amino-5-methyl- (7CI,8CI,9CI)(15981-91-6)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-amino-5-methyl- (7CI,8CI,9CI)(15981-91-6)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 15981-91-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 28, p. 231, 1991 DOI: 10.1002/jhet.5570280205

InChI:InChI=1/C5H7N3O/c1-3-2-7-5(6)8-4(3)9/h2H,1H3,(H3,6,7,8,9)

Upstream product

• 107-31-3 Methyl formate 
• 50-01-1 guanidine hydrochloride 
• 105-37-3 Ethyl propionate 
• 113-00-8 guanidine nitrate 
• 190274-88-5 1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-[(N,N-dimethylamino)methylidene]amino-5-methyl-4(1H)-pyrimidinone 
• 19316-88-2 2-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-methylpyridin-4(1H)-one 
• 27772-62-9 ethyl 2-formylpropionate 
• 4401-71-2 1,3-dimethylthymine 
• 608-41-3 3-methylmalic acid 

Downstream Products

• 1292200-66-8 Fmoc-PNA-iC(Boc)-OBn 
• 884593-04-8 N²-benzoyl-1-(3-O-benzoyl-4-O-[bis(4-methoxyphenyl)phenylmethyl]-β-D-ribopyranosyl)-5-methylisocytosine 
• 884592-97-6 N²-benzoyl-5-methylisocytosine 
• 65-71-4 thymin 

Relevant articles and documents

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HETEROARYL DERIVATIVES AS CFTR MODULATORS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

NOVEL RING TRANSFORMATION REACTIONS AND THEIR APPLICATIONS TO THE SYNTHESES OF POTENTIAL ANTICANCER HETEROCYCLIC COMPOUNDS

Novel heterocyclic ring trasformation reactions developed recently in our laboratory are described.They include pyrimidine to pyrimidine, pyrimidine to pyridine transformations.Also discussed are novel one-step procedures for conversion of 1,3-dimethyluracil derivatives into the pyridopyrimidine system.Some applications of these novel reactions to the syntheses of compounds of biological interest are also described.