159874-38-1

Basic information

• Product Name: 4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: 1-N-CBZ-4-ETHYLAMINOPIPERIDINE;benzyl 4-(ethylamino)piperidine-1-carboxylate;benzyl 4-(ethylamino)piperidine-1-carboxylate hydrochloride;4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER-HCl;N-CBZ-4-EthylaMinopiperidine;4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• CAS NO: 159874-38-1
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.35
• Mol File: 159874-38-1.mol

Chemical Properties

• Boiling Point: 388.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.10
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.24±0.20(Predicted)
• CAS DataBase Reference: 4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(159874-38-1)
• EPA Substance Registry System: 4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(159874-38-1)

Safety Data

• Hazardous Substances Data: 159874-38-1(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as a building block for the synthesis of pharmaceuticals and biologically active compounds, leveraging its structural properties to contribute to the development of new medications.
Used in Drug Development:
In the pharmaceutical industry, 4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as a precursor to other useful chemicals, playing a crucial role in the advancement of drug candidates and the optimization of drug structures.
Used in Organic Synthesis:
4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is utilized as a protective group for amine functions during organic synthesis, ensuring the selective reaction of other functional groups without affecting the amine, which is vital for the synthesis of complex organic molecules and pharmaceuticals.
Used in Pharmaceutical Intermediates:
4-ETHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER serves as an intermediate in the production of various pharmaceuticals, facilitating the synthesis of final drug products by providing a stable and easily modifiable starting material.

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 75-04-7 ethylamine 

Downstream Products

• 895541-70-5 tert-butyl 4-{2-[{1-[(benzyloxy)carbonyl]piperidin-4-yl}(ethyl)amino]-2-oxoethyl}piperazine-1-carboxylate 
• 895541-71-6 tert-butyl 4-{2-[{1-[(benzyloxy)carbonyl]piperidin-4-yl}(ethyl)amino]-2-oxoethyl}piperidine-1-carboxylate 
• 159874-41-6 1-Benzyloxycarbonyl-4-(N-ethylbutyramido)piperidine 
• 159874-42-7 1-Benzyloxycarbonyl-4-(N-ethylisobutyramido)piperidine 
• 1131739-50-8 4-(ethyl-methanesulfonyl-amino)-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

PIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS

The invention relates to a compound of formula wherein Ar1, Ar2, R1, R2, R3, R4, R5, and R5′ or to a pharmaceutically active salt thereof. The compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).

CARBOXAMIDE DERIVATIVES FOR TREATING ASTHMA

The present invention concerns novel carboxamide derivatives of formula I, set out hereinbelow which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives. STR1