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CAS

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1599432-08-2

NIBR189, also known as (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one, is a selective Epstein-Barr virus-induced gene 2 (EBI-2) receptor antagonist. It plays a crucial role in modulating immune responses, particularly those related to auto-immune diseases. NIBR189 has the potential to be a promising pharmaceutical candidate for various applications in the medical field.

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  • 1599432-08-2 Structure

  • Basic information

    1. Product Name: NIBR189
    2. Synonyms: NIBR189;(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one;(2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one
    3. CAS NO:1599432-08-2
    4. Molecular Formula: C21H21BrN2O3
    5. Molecular Weight: 429.32
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1599432-08-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 639.7±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.403±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    9. PKA: -0.86±0.70(Predicted)
    10. CAS DataBase Reference: NIBR189(CAS DataBase Reference)
    11. NIST Chemistry Reference: NIBR189(1599432-08-2)
    12. EPA Substance Registry System: NIBR189(1599432-08-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1599432-08-2(Hazardous Substances Data)

1599432-08-2 Usage

Uses

Used in Pharmaceutical Industry:
NIBR189 is used as a selective EBI-2 receptor antagonist for modulating immune responses related to auto-immune diseases. By targeting the EBI-2 receptor, NIBR189 can potentially help in the treatment and management of various auto-immune conditions.
Used in Auto-immune Disease Treatment:
NIBR189 is used as a therapeutic agent for the treatment of auto-immune diseases. Its selective antagonism of the EBI-2 receptor can help in regulating the immune system and reducing the severity of auto-immune reactions, leading to improved patient outcomes.
Used in Immunological Research:
NIBR189 is used as a research tool for studying the role of EBI-2 receptors in immune responses and auto-immune diseases. Its selective antagonism can provide valuable insights into the underlying mechanisms of these conditions and contribute to the development of novel therapeutic strategies.

Biological Activity

nibr189 is a small molecule antagonist of the epstein-barr virus-induced gene 2 (ebi2; gpr183) receptor with ic50 of 16 nm(binding) and 11 nm (functional).

Check Digit Verification of cas no

The CAS Registry Mumber 1599432-08-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,9,4,3 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1599432-08:
(9*1)+(8*5)+(7*9)+(6*9)+(5*4)+(4*3)+(3*2)+(2*0)+(1*8)=212
212 % 10 = 2
So 1599432-08-2 is a valid CAS Registry Number.

1599432-08-2Downstream Products

1599432-08-2Relevant articles and documents

Identification and characterization of small molecule modulators of the epstein-barr virus-induced gene 2 (EBI2) receptor

Gessier, Francois,Preuss, Inga,Yin, Hong,Rosenkilde, Mette M.,Laurent, Stephane,Endres, Ralf,Chen, Yu A.,Marsilje, Thomas H.,Seuwen, Klaus,Nguyen, Deborah G.,Sailer, Andreas W.

, p. 3358 - 3368 (2014/05/20)

Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called EBI2 (aka GPR183) (Nature 2011, 475, 524; 519). EBI2 is highly expressed in immune cells (J. Biol. Chem. 2006, 281, 13199), and its activation has been sho

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