- A novel and convenient route for the construction of 5-((1H-1,2,4-triazol- 1-yl)methyl)-1H-indoles and its application in the synthesis of Rizatriptan
-
In this study, a novel and convenient route for the construction of 5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indoles (8) is presented starting from (1H-1,2,4-triazol-1-yl)methanol (5) and indolines (6) under 98% H 2SO4 at room temperature for 4-24 h, followed by deacetylation and dehydrogenation. Based on this finding, a novel route to synthesize Rizatriptan starting from tryptamine was designed and accomplished with 48.5% overall yield in 6 steps. Compared with operational art, the new route afforded higher yield and more pure products requiring no chromatographic purification, which may further be applied in industrialization.
- He, Yi,Li, Xiaolong,Li, Jue,Li, Xiaocen,Guo, Li,Hai, Li,Wu, Yong
-
p. 3938 - 3941
(2014/07/08)
-
- Efficient synthesis of impurity-C of antimigraine agent Rizatriptan benzoate
-
During the commercial manufacturing of antimigraine drug Rizatriptan benzoate, several impurities are reported to be formed. This present work demonstrates a convergent and short synthesis of the most critical impurity (C) of Rizatriptan, [2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indole-2-yl)-N,N- dimethylethanamine (1)], recently reported in U.S. Pharmacopeia.
- Pramanik, Chinmoy,Bhumkar, Rahul,Karhade, Ganesh,Khairnar, Pravinkumar,Tripathy, Narendra Kumar,Gurjar, Mukund K.
-
experimental part
p. 507 - 511
(2012/08/08)
-
- A new synthesis of rizatriptan based on radical cyclization
-
A new methodology useful for preparation of indole derivatives bearing a 2-(dialkylamino)-ethyl substituent at the 3-position has been developed. Application of this methodology to the synthesis of N,N-dimethyl-2-{5-[(1H-1,2, 4-triazol-1-yl)methyl]-1H-indol-3-yl}ethan-1-amine (rizatriptan; 3) is described. The key reaction step is based on the radical cyclization of N-[4-(dimethylamino)but-2-yn-1-yl]-N-(2-iodo-4-[(1H-1,2,4-triazol-1-yl)methyl] phenyl}-acetamide (21), easily available by the Mannich reaction, and subsequent isomerization of the primarily formed methylidene derivative 22.
- Radl, Stanislav,Klecan, Ondrej,Klvana, Robert,Havlicek, Jaroslav
-
p. 116 - 126
(2008/09/21)
-
- Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction
-
Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.
- Chen, Cheng-Yi,Lieberman, David R.,Larsen, Robert D.,Reamer, Robert A.,Verhoeven, Thomas R.,Reider, Paul J.,Cottrell, Ian F.,Houghton, Peter G.
-
p. 6981 - 6984
(2007/10/02)
-
