- Furanocoumarin glucosides from the seeds of Apium graveolens
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Besides celereoside and nodakenin, three new furanocoumarin glucosides have been isolated from the seeds of Apium graveolens. The new glucosides have been structurally assigned as (+)-2,3,-dihydro-9-hydroxy-2[1-(6-sinapinoyl) β-d-glucosyloxy-1-methylethyl]-7H-furo[3,2g] [1]-benzopyran-7-one, (-)-2,3-dihydro-9-O-β-d-gluco-syloxy-2-isopropenyl-7H-furo[3,2g] [1]-benzopyran-7-one, and 5-methoxy-8-O-β-d-glucosyloxypsoralen.
- Ahluwalia, Vinod K.,Boyd, Derek R.,Jain, Anil K.,Khanduri,Sharma, Narain D.
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- Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
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The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.
- Marumoto, Shinsuke,Miyazawa, Mitsuo
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supporting information; experimental part
p. 784 - 788
(2012/03/22)
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- COUMARINS FROM THE ROOTS OF FERONIA LIMONIA
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A new monoterpenoidfuranocoumarin lactone (fernolin) along with aurapten, marmesin, bergapten and xanthotoxin has been isolated from the roots of Feronia limonia.The structure of each of these compounds has been established on the basis of chemical reactions and spectral studies.Key Word Index - Feronia limonia; Rutaceae; roots; coumarins.
- Agrawal, Amulaya,Siddiqui, I. R.,Singh, J.
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p. 1229 - 1232
(2007/10/02)
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