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1604812-35-2

Azilsartan iMpurity, also known as Azilsartan Dimer, is an impurity found in Azilsartan (A926900), which is a pharmaceutical compound used as an analgesic and anti-inflammatory drug containing angiotensin II antagonists. These antagonists play a crucial role in blocking the action of angiotensin II, a potent vasoconstrictor, thereby helping to lower blood pressure and alleviate pain and inflammation.

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  • (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphe

    Cas No: 1604812-35-2

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  • (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxyla

    Cas No: 1604812-35-2

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  • 1604812-35-2 Structure

  • Basic information

    1. Product Name: Azilsartan iMpurity
    2. Synonyms: Azilsartan iMpurity;(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate;Azilsartan Impurity 23
    3. CAS NO:1604812-35-2
    4. Molecular Formula: C35H28N4O11
    5. Molecular Weight: 680.62
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1604812-35-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 813.4±75.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.48±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 4°C
    8. Solubility: Chloroform (Slightly), Methanol (Slightly)
    9. PKA: 4.07±0.10(Predicted)
    10. CAS DataBase Reference: Azilsartan iMpurity(CAS DataBase Reference)
    11. NIST Chemistry Reference: Azilsartan iMpurity(1604812-35-2)
    12. EPA Substance Registry System: Azilsartan iMpurity(1604812-35-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1604812-35-2(Hazardous Substances Data)

1604812-35-2 Usage

Uses

Used in Pharmaceutical Industry:
Azilsartan iMpurity is used as a reference material for the development and validation of analytical methods in the pharmaceutical industry. It is essential for quality control and assurance processes to ensure the purity, safety, and efficacy of the final drug product, Azilsartan.
Additionally, understanding the properties and effects of Azilsartan iMpurity can contribute to the optimization of the drug synthesis process, potentially leading to improved drug formulations with reduced impurities and enhanced therapeutic benefits.

Check Digit Verification of cas no

The CAS Registry Mumber 1604812-35-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,0,4,8,1 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1604812-35:
(9*1)+(8*6)+(7*0)+(6*4)+(5*8)+(4*1)+(3*2)+(2*3)+(1*5)=142
142 % 10 = 2
So 1604812-35-2 is a valid CAS Registry Number.

1604812-35-2Downstream Products

1604812-35-2Relevant articles and documents

A high-purity [...] impurity synthetic method (by machine translation)

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Paragraph 0021-0026; 0029-0053, (2018/12/02)

The invention discloses a high-purity [...] impurity synthesis method, the method to [...] as raw materials, with 4 - chloromethyl - 5 - methyl - 1, 3 - dioxo heterocyclic pentene - 2 - one in the alkaline organic solvent in the reaction, make [...] impur

Preparation method of azilsartan medoxomil process impurities

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Paragraph 0130; 0131; 0132; 0133, (2018/11/27)

The invention provides a preparation method of azilsartan medoxomil process impurities. The method comprises the following steps: A) azilsartan medoxomil A4 is dissolved in an organic solvent; or azilsartan medoxomil A4 is hydrolyzed to obtain azilsartan, and the azilsartan is dissolved in the organic solvent; B) a catalyst and alkali are added and stirred at the temperature of 0-5 DEG C; C) a DMFsolution of 4-halomethyl-5-methyl-1,3-dioxole-2-ketone is added in a reaction system, after charging is completed, a heating reaction is carried out, acid addition is carried out to adjust a pH value, and filtering is carried out to obtain a product. A synthesis route f the azilsartan medoxomil process impurities is designed, the azilsartan medoxomil process impurities can be successfully obtained with high yield, and a qualified impurities reference substance is obtained.

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