147403-52-9

Basic information

• Product Name: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester
• Synonyms: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester;Methyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-1H-benzo[d]iMidazole-7-carboxylate;(Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycarbonyloxy)carbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate;1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester;Methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-1H-benzo[d]iMidazole-7-carboxylate;1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester;AzilsartanMedoxoMilInterMediates-2;Azilsartan Methyl ester
• CAS NO: 147403-52-9
• Molecular Formula: C₂₆H₂₂N₄O₅
• Molecular Weight: 470.47668
• EINECS: 1312995-182-4
• Product Categories: Intermediates;Fine Chemicals
• Mol File: 147403-52-9.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Density: 1.36
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Very Slightly)
• PKA: 6.99±0.20(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester(147403-52-9)
• EPA Substance Registry System: 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester(147403-52-9)

Safety Data

• Hazardous Substances Data: 147403-52-9(Hazardous Substances Data)

Usage

Description

1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl] -2-ethoxy-, methyl ester is a complex organic compound with a molecular structure that features a benzimidazole core, an oxadiazol-3-yl group, and a biphenyl-4-ylmethyl moiety. It also contains an ethoxy group and a methyl ester functional group. 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl] -2-ethoxy-, methyl ester is characterized by its unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl] -2-ethoxy-, methyl ester is used as a pharmaceutical compound for the development of new drugs. Its unique molecular structure and functional groups make it a promising candidate for targeting specific biological pathways and receptors, potentially leading to the development of novel therapeutic agents.
Used in Chemical Research:
In the field of chemical research, this compound can be used as a starting material or intermediate for the synthesis of more complex molecules with specific properties and applications. Its unique structure and functional groups can be further modified or used in the development of new chemical entities with potential uses in various industries.
Used in Material Science:
The compound's unique molecular structure and properties may also find applications in material science, where it could be used to develop new materials with specific characteristics, such as improved mechanical, electrical, or optical properties. These materials could have potential uses in various industries, including electronics, aerospace, and automotive.

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 136304-78-4 methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate 
• 139481-28-0 methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate 
• 541-41-3 chloroformic acid ethyl ester 
• 139481-44-0 methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate 
• 147404-82-8 methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 911314-60-8 4'-(bromomethyl)biphenyl-2-carbaldehyde 
• 150058-27-8 2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester 
• 67-64-1 acetone 
• 124-38-9 carbon dioxide 
• 147403-65-4 methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 1397836-41-7 ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 

Downstream Products

• 863031-21-4 Azilsartan medoxomil 
• 1417576-00-1 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1’-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate 
• 1417576-01-2 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 1604812-35-2 C₃₅H₂₈N₄O₁₁ 
• 1499167-76-8 methyl 2-ethoxy-1-((2'-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 1403474-78-1 methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate 
• 147403-03-0 azilsartan 

Relevant articles and documents

AZILSARTAN ALKYL ESTER, METHOD FOR PRODUCING AZILSARTAN METHYL ESTER, AND METHOD FOR PRODUCING AZILSARTAN

PROBLEM TO BE SOLVED: To provide azilsartan alkyl ester to be an intermediate of azilsartan, and a method for producing azilsartan methyl ester having a novel crystal form, and a method for producing high-purity azilsartan from an obtained compound. SOLUTION: The present invention provides a method for producing high-purity azilsartan alkyl ester and/or azilsartan methyl ester by crystallizing azilsartan alkyl ester and/or azilsartan methyl ester in acetone or a solvent mixture of acetone and alcohol. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2021,JPOandINPIT

Synthesis technology for continuously preparing azilsartan in micro-channel reactor

The invention discloses a synthesis technology for continuously preparing azilsartan in a micro-channel reactor. The technology comprises the following steps: (1) adding SM-1, an aqueous hydroxylaminesolution and triethylamine into anhydrous ethanol, and performing a reaction to obtain an intermediate TAK1; (2) preparing a homogeneous solution A from the TAK1, triethylamine and dioxane; (3) preparing a homogeneous solution B from solid phosgene and dioxane; (4) dissolving sodium hydroxide in water to prepare a homogeneous solution C; (5) respectively pumping the homogeneous solution A and thehomogeneous solution B into a microstructure mixer I in a micro-channel reaction device at the same time, performing mixing, and introducing the obtained mixed solution into a microstructure reactorI; (6) respectively pumping the homogeneous solution C and the effluent of the microstructure reactor I into a microstructure mixer II in the micro-channel reaction device at the same time while step(5) is carried out, performing mixing, and introducing the obtained mixed solution into a microstructure reactor II; and (7) collecting the effluent of the microstructure reactor II to obtain the product azilsartan.

Preparation 2 - ethoxy - 1 - {[2' - (5 - oxo - 4, 5 - dihydro - 1, 2, 4 - oxadiazol - 3 - yl) biphenyl - 4 - yl] methyl} - 1 H - benzimidazole - 7 - carboxylic acid

The invention provides a novel method for preparing 2- ethyoxyl-1-{[2'-(5-carbonyl-4,5-dihydro-1,2,4-oxadiazole-3-yl) xenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid. The novel method comprises the steps of providing a novel intermediate in 2-ethyoxyl-1-{[2'-(5-carbonyl-4,5-dihydro-1,2,4-oxadiazole-3-yl)xenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid (azilsartan) preparation, wherein the intermediate is as shown in formula (A); X is H or halogen. By preparing the intermediate with the formula (A), azilsartan can be conveniently and quickly prepared; and moreover, the novel method is short in reaction route, less in byproduct, high in total yield, gentle in condition and suitable for industrially preparing azilsartan.