160706-82-1

Basic information

• Product Name: Pyrrolo[1,2-a]pyrazine-1,4-dione, 3-ethylidenehexahydro-, (S)- (9CI)
• Synonyms: Pyrrolo[1,2-a]pyrazine-1,4-dione, 3-ethylidenehexahydro-, (S)- (9CI);(3Z,8AS)-3-ETHYLIDENEHEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
• CAS NO: 160706-82-1
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.20378
• Product Categories: PIPERIDINE;PYRROLE
• Mol File: 160706-82-1.mol

Chemical Properties

• Boiling Point: 503.2±43.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 11.98±0.20(Predicted)
• CAS DataBase Reference: Pyrrolo[1,2-a]pyrazine-1,4-dione, 3-ethylidenehexahydro-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-a]pyrazine-1,4-dione, 3-ethylidenehexahydro-, (S)- (9CI)(160706-82-1)
• EPA Substance Registry System: Pyrrolo[1,2-a]pyrazine-1,4-dione, 3-ethylidenehexahydro-, (S)- (9CI)(160706-82-1)

Safety Data

• Hazardous Substances Data: 160706-82-1(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 600-18-0 2-Oxobutyric acid 
• 75-07-0 acetaldehyde 
• 114604-94-3 (8αS)-(1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-yl)-phosphonic acid dimethyl ester 

Relevant articles and documents

Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors

The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.

WHAT IS THE STRUCTURE OF BARETTIN ? NOVEL SYNTHESIS OF UNSATURATED DIKETOPIPERAZINES.

Several unsaturated diketopiperazines 1a-1f as well as a compound with the proposed structure 2 of barettin were synthesized by a new method via esters of diketopiperazine phosphonic acid.The proposed structure of barettin was found to be incorrect.