Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors
The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.
Li, Wen-Ren,Peng, Shao-Zheng
p. 7373 - 7376
(2007/10/03)
WHAT IS THE STRUCTURE OF BARETTIN ? NOVEL SYNTHESIS OF UNSATURATED DIKETOPIPERAZINES.
Several unsaturated diketopiperazines 1a-1f as well as a compound with the proposed structure 2 of barettin were synthesized by a new method via esters of diketopiperazine phosphonic acid.The proposed structure of barettin was found to be incorrect.
Lieberknecht, Albrecht,Griesser, Helmut
p. 4275 - 4278
(2007/10/02)
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