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High purity L(-)-Proline 98% CAS:147-85-3
Cas No: 147-85-3
USD $ 15.0-23.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
L-Proline
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L-Proline 147-85-3
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L- proline
Cas No: 147-85-3
USD $ 16.0-100.0 / Kilogram 1 Kilogram 100 Kilogram/Month Greenutra Resource Inc Contact Supplier
L-Proline Manufacturer/High quality/Best price/In stock
Cas No: 147-85-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 2-pyrrolidinecarboxylic acid supplier in China
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L-Proline CAS NO.147-85-3
Cas No: 147-85-3
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
good quality L-Proline
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Factory supply high quality L-Proline,147-85-3
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L-Proline CAS: 147-85-3
Cas No: 147-85-3
USD $ 10.0-20.0 / Gram 100 Gram 10 Metric Ton/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier

147-85-3 Usage

Purification Methods

A likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl ether, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]

Uses

amino acid, nutrient

Uses

L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.

Chemical Properties

White crystalline powder
InChI:InChI=1/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

147-85-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1568506)  L-Proline  United States Pharmacopeia (USP) Reference Standard 147-85-3 1568506-200MG 4,662.45CNY Detail
Sigma (81709)  L-Proline  BioUltra, ≥99.5% (NT) 147-85-3 81709-100G 1,926.99CNY Detail
Sigma (81709)  L-Proline  BioUltra, ≥99.5% (NT) 147-85-3 81709-25G 575.64CNY Detail
Sigma (81709)  L-Proline  BioUltra, ≥99.5% (NT) 147-85-3 81709-10G 526.50CNY Detail
Sigma (P8865)  L-Proline  PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture 147-85-3 P8865-10KG 75,231.00CNY Detail
Sigma (P8865)  L-Proline  PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture 147-85-3 P8865-1KG 11,571.30CNY Detail
Sigma (P8865)  L-Proline  PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture 147-85-3 P8865-100G 3,111.03CNY Detail
Sigma (P5607)  L-Proline  from non-animal source, meets EP, USP testing specifications, suitable for cell culture 147-85-3 P5607-1KG 4,000.23CNY Detail
Sigma (P5607)  L-Proline  from non-animal source, meets EP, USP testing specifications, suitable for cell culture 147-85-3 P5607-100G 439.92CNY Detail
Sigma (P5607)  L-Proline  from non-animal source, meets EP, USP testing specifications, suitable for cell culture 147-85-3 P5607-25G 400.14CNY Detail
Sigma-Aldrich (P3350000)  Proline  European Pharmacopoeia (EP) Reference Standard 147-85-3 P3350000 1,880.19CNY Detail
Vetec (V900338)  L-Proline  Vetec reagent grade, ≥99% 147-85-3 V900338-500G 684.45CNY Detail

147-85-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name L-proline

1.2 Other means of identification

Product number -
Other names QCR-1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147-85-3 SDS

147-85-3Synthetic route

(2S)-N-allyloxycarbonyl-L-proline
110637-44-0

(2S)-N-allyloxycarbonyl-L-proline

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With diethylamine; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine In water; acetonitrile for 0.25h; Ambient temperature;100%
(S)-Pyrrolidine-2-carboxylic acid 3-methyl-but-2-enyl ester

(S)-Pyrrolidine-2-carboxylic acid 3-methyl-but-2-enyl ester

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With diethylamine; Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) In water; acetonitrile for 0.75h;100%
1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With water at 170℃; for 0.05h; Microwave irradiation;100%
With tin(IV) chloride In ethyl acetate for 0.583333h; Ambient temperature;98%
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;96%
N-Benzyloxycarbonyl-L-proline
1148-11-4

N-Benzyloxycarbonyl-L-proline

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate at 80℃; for 0.0833333h; Microwave irradiation;100%
With hydrogen; hydroxyapatite-bound Pd In methanol at 40℃; for 1h;99%
With hydrogen; palladium on activated charcoal In ethyl acetate at 80℃; under 2585.81 Torr; for 0.0833333h; microwave irradiation;99%
Poc-Pro-OH
439912-48-8

Poc-Pro-OH

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With resin bound tetrathiomolybdate In methanol at 28℃; for 1.5h; ultrasonic bath;100%
D-Prolin
344-25-2

D-Prolin

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With porcine kidney D-amino acid oxidase (EC 1.4.3.3.); sodium cyanoborohydride; flavin adenine dinucleotide In phosphate buffer at 37℃;99%
lithium salicylate
552-38-5

lithium salicylate

A

Lithium Salicylate Proline

Lithium Salicylate Proline

B

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
A n/a
B 99%
L-1-(chlorocarbonyl)proline ethyl ester
86050-92-2

L-1-(chlorocarbonyl)proline ethyl ester

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride at 25 - 75℃;98%
N-BOC-proline tert-butyl ester
91237-84-2

N-BOC-proline tert-butyl ester

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 2h;98%
With trifluoroacetic acid82%
(S)-methyl 1-(chlorocarbonyl)pyrrolidine-2-carboxylate
85665-59-4

(S)-methyl 1-(chlorocarbonyl)pyrrolidine-2-carboxylate

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride at 25 - 75℃;97%
Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

A

9-methylene-fluorene
4425-82-5

9-methylene-fluorene

B

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With dimethyl sulfoxide at 120℃; for 0.333333h;A n/a
B 96%
(3RS,6S)-3-[di(methoxycarbonyl)methyl]-1,6-trimethylene-2,5-piperazinedione
1319113-54-6

(3RS,6S)-3-[di(methoxycarbonyl)methyl]-1,6-trimethylene-2,5-piperazinedione

A

D-aspartic acid hydrochloride
71855-54-4

D-aspartic acid hydrochloride

B

L-aspartic acid hydrochloride
17585-59-0

L-aspartic acid hydrochloride

C

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 24h;A n/a
B n/a
C 95%
(2S)-N-allyloxycarbonyl-L-proline
110637-44-0

(2S)-N-allyloxycarbonyl-L-proline

A

L-proline
147-85-3

L-proline

B

(S)-1-allylproline
610299-77-9

(S)-1-allylproline

Conditions
ConditionsYield
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20 - 40℃;A 93%
B n/a
L-prolinamide
7531-52-4

L-prolinamide

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
Stage #1: L-prolinamide With hydrogenchloride for 10h; Heating;
Stage #2: With methyloxirane In ethanol at 20℃; for 5h;
92%
Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 50℃; for 3h;92%
C5H9NO2*H3N*ClH

C5H9NO2*H3N*ClH

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane92%
L-prolinamide hydrochloride
42429-27-6

L-prolinamide hydrochloride

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With Amberlyst 15; water at 100℃; for 72h;90%
cinnamyl-L-prolinate

cinnamyl-L-prolinate

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With diethylamine; Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) In water; acetonitrile for 0.666667h;86%
(S)-1-allylproline
610299-77-9

(S)-1-allylproline

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 40℃;86%
phenol
108-95-2

phenol

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
86%
(3R,6S,1'RS)-3-(methoxycarbonylcyanomethyl)-1,6-trimethylene-2,5-piperazinedione
1319113-56-8

(3R,6S,1'RS)-3-(methoxycarbonylcyanomethyl)-1,6-trimethylene-2,5-piperazinedione

A

D-aspartic acid hydrochloride
71855-54-4

D-aspartic acid hydrochloride

B

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 24h;A 84%
B 82%
(S)-tetrahydro-3'H-9λ4-boraspiro[bicyclo[3.3.1]nonane-9,1'-pyrrolo[1,2-c][1,3,2]oxazaborol]-3'-one

(S)-tetrahydro-3'H-9λ4-boraspiro[bicyclo[3.3.1]nonane-9,1'-pyrrolo[1,2-c][1,3,2]oxazaborol]-3'-one

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 7h;82%
(3R,8aS)-hexahydro-3-(prop-2-enyl)pyrrolo[1,2-a]pyrazine-1,4-dione
205875-07-6

(3R,8aS)-hexahydro-3-(prop-2-enyl)pyrrolo[1,2-a]pyrazine-1,4-dione

A

D-allylglycine
54594-06-8

D-allylglycine

B

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 10h;A 80%
B 62%
L-proline (+)-10-camphorsulfonic acid salt

L-proline (+)-10-camphorsulfonic acid salt

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 0.5h;78%
L-proline methanesulfonic acid salt

L-proline methanesulfonic acid salt

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 0.5h; Solvent;70%
L-ornithine
70-26-8

L-ornithine

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
platinum(IV) oxide; Pt/titania In water for 41h; Irradiation; pH 9.8;43%
platinum(IV) oxide; Pt/titania In water for 41h; Product distribution; Irradiation; pH 9.8; other amino acids and derivatives; other catalyst and rection time;
With Pseudomonas putida N-methyl-L-amino acid dehydrogenase; T. viride L-lysine oxidase; Tris buffer; flavin adenine dinucleotide; catalase In various solvent(s) at 30℃; for 2h; pH=8.0;
With benzenesulfonamide; ornithine cyclodeaminase; NAD In various solvent(s) at 30℃; pH=8.0;
With NAD; dehydrogenase from Candida boidinii; pyrroline-5-carboxylate reductase from Halomonas elongata; transaminase from Halomonas elongata; 2-oxo-propionic acid In aq. buffer at 37℃; pH=10; Reagent/catalyst; Enzymatic reaction;
(S)-proline (S)-1,1'-bi-2-naphthol 1:2 complex

(S)-proline (S)-1,1'-bi-2-naphthol 1:2 complex

(S)-[1,1']-binaphthalenyl-2,2'-diol
18531-99-2

(S)-[1,1']-binaphthalenyl-2,2'-diol

B

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
In water; ethyl acetate at 20℃; for 2h;A 42%
B 0.257 g
methanol
67-56-1

methanol

L-proline
147-85-3

L-proline

methyl (2S)-pyrrolidine carboxylate
2577-48-2

methyl (2S)-pyrrolidine carboxylate

Conditions
ConditionsYield
With hydrogenchloride for 2h; Heating;100%
With thionyl chloride Heating;100%
With sulfuryl dichloride100%
benzoyl chloride
98-88-4

benzoyl chloride

L-proline
147-85-3

L-proline

N-(benzoyl)-L-proline
5874-58-8

N-(benzoyl)-L-proline

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 0 - 20℃;100%
With sodium hydroxide In water at 0℃; for 2h;89%
With potassium carbonate In tetrahydrofuran at 60℃;85%
benzyl chloroformate
501-53-1

benzyl chloroformate

L-proline
147-85-3

L-proline

N-Benzyloxycarbonyl-L-proline
1148-11-4

N-Benzyloxycarbonyl-L-proline

Conditions
ConditionsYield
With sodium hydroxide In water for 13.5h; Ambient temperature;100%
With sodium carbonate at 0 - 20℃; for 3h;100%
With sodium hydroxide at 0℃; for 0.166667h;97%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

L-proline
147-85-3

L-proline

L-N-tosyl-proline
51077-01-1, 110771-95-4

L-N-tosyl-proline

Conditions
ConditionsYield
With sodium carbonate Inert atmosphere;100%
With water; sodium hydroxide at 70℃; for 2h;99%
In sodium hydroxide98.3%
L-proline
147-85-3

L-proline

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

Conditions
ConditionsYield
Stage #1: L-proline With lithium aluminium tetrahydride In tetrahydrofuran for 1.25h; Heating / reflux;
Stage #2: With potassium hydroxide In tetrahydrofuran; water for 1.25h; Heating / reflux;
100%
Stage #1: L-proline With lithium aluminium tetrahydride In tetrahydrofuran Inert atmosphere; Cooling with ice; Reflux;
Stage #2: With potassium hydroxide In tetrahydrofuran at 20℃; Reflux;
99%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 72.5h; Reflux;99%
methanol
67-56-1

methanol

L-proline
147-85-3

L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With thionyl chloride for 1.5h; Heating;100%
With hydrogenchloride for 4h; Ambient temperature;100%
With thionyl chloride for 1.5h; Heating;100%
isatoic anhydride
118-48-9

isatoic anhydride

L-proline
147-85-3

L-proline

(S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione
24919-40-2, 60269-66-1, 18877-34-4

(S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 160℃; for 4h;100%
In dimethyl sulfoxide at 180℃; Condensation;96%
In dimethyl sulfoxide at 100℃; for 4h;95%
ethanol
64-17-5

ethanol

L-proline
147-85-3

L-proline

L-proline ethyl ester monohydrochloride
33305-75-8

L-proline ethyl ester monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 1h; Heating;100%
With thionyl chloride for 12h; Reflux; Green chemistry;99%
Stage #1: L-proline With thionyl chloride In ethanol for 6h; Heating;
Stage #2: ethanol Further stages.;
98%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-proline
147-85-3

L-proline

1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 19h; Cooling with ice;100%
With amberlyst-15 In ethanol at 20℃; for 0.0833333h; chemoselective reaction;100%
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; for 16h;100%
methanol
67-56-1

methanol

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

L-proline
147-85-3

L-proline

(S)-proline-N-ethyl carbamate methyl ester
77581-28-3, 93423-88-2

(S)-proline-N-ethyl carbamate methyl ester

Conditions
ConditionsYield
With potassium carbonate In methanol100%
With potassium carbonate at 0 - 20℃;100%
With potassium carbonate at 0 - 20℃; for 7.5h; Inert atmosphere;100%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

L-proline
147-85-3

L-proline

(S)-N-(ethoxycarbonyl)proline
5700-74-3

(S)-N-(ethoxycarbonyl)proline

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran at 0℃; for 2h;100%
Stage #1: chloroformic acid ethyl ester; L-proline With sodium hydroxide; water at 0 - 20℃; pH=9 - 10;
Stage #2: With hydrogenchloride; water at 0℃; pH=1;
100%
With sodium hydrogencarbonate In water at 25℃; for 12h;96%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

L-proline
147-85-3

L-proline

N-benzenesulfonyl-L-proline
88425-46-1

N-benzenesulfonyl-L-proline

Conditions
ConditionsYield
With sodium carbonate In water for 5h;100%
With sodium carbonate In water for 4h;100%
With sodium carbonate In water at -5 - 20℃; for 4h; Inert atmosphere;100%
ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

L-proline
147-85-3

L-proline

N-(2-methylbenzoyl)-L-proline

N-(2-methylbenzoyl)-L-proline

Conditions
ConditionsYield
With sodium hydroxide for 0.5h;100%
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃;0.77 g
Conditions
ConditionsYield
With ferrous(II) sulfate heptahydrate; cis-3-proline hydroxylase type II; sodium L-ascorbate at 37℃; for 16h; stereospecific reaction;100%
With iron(II) sulfate; α-ketoglutaric acid disodium salt In culture medium at 28℃; for 72h; Enzymatic reaction; regioselective reaction;61%
With 4-morpholineethanesulfonic acid; α-ketoglutaric acid; bovine serum albumin; proline 3-hydroxylase; iron(II) sulfate In water pH=6.0; Oxidation; hydroxylation;
With hydrogenchloride; α-ketoglutaric acid; ammonium iron (II) sulfate; L-proline cis-3-hydroxylase type I; sodium L-ascorbate In aq. buffer at 21℃; for 14h; pH=6.5; Enzymatic reaction;> 95 %Chromat.
With ferrous(II) sulfate heptahydrate; α-ketoglutaric acid disodium salt; ascorbic acid In aq. phosphate buffer at 37℃; for 16h; pH=7.5; Enzymatic reaction;530 mg
tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

L-proline
147-85-3

L-proline

proline, tetrabutylammonium carboxylate salt

proline, tetrabutylammonium carboxylate salt

Conditions
ConditionsYield
In methanol at 0 - 20℃; for 3h; Inert atmosphere;100%
In methanol97%
In water at 20℃; for 2h;95%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

L-proline
147-85-3

L-proline

(S)-N-(2-nitrophenyl)proline
31981-54-1

(S)-N-(2-nitrophenyl)proline

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water for 5h; Heating;100%
With sodium hydrogencarbonate In ethanol; water Heating;94%
With triethylamine In dimethyl sulfoxide80.3%
With sodium hydrogencarbonate In ethanol; water at 100℃;
Allyl chloroformate
2937-50-0

Allyl chloroformate

L-proline
147-85-3

L-proline

(2S)-N-allyloxycarbonyl-L-proline
110637-44-0

(2S)-N-allyloxycarbonyl-L-proline

Conditions
ConditionsYield
With sodium hydrogencarbonate In diethyl ether at 20℃; for 16h;100%
With hydrogenchloride; sodium hydroxide In tetrahydrofuran; water
N-benzyloxycarbonyl-(2S)-aminobutyric acid succinimide ester
71447-81-9

N-benzyloxycarbonyl-(2S)-aminobutyric acid succinimide ester

L-proline
147-85-3

L-proline

N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline
185212-64-0

N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water at 20℃;100%
3-benzo[b]thiophen-2-yl-3-tert-butoxycarbonylamino-propionic acid
776330-84-8

3-benzo[b]thiophen-2-yl-3-tert-butoxycarbonylamino-propionic acid

L-proline
147-85-3

L-proline

[1-benzo[b]thiophen-2-yl-3-(2-S-carbamoyl-pyrrolidin-1-yl)-3-oxo-propyl]-carbamic acid tert-butyl ester
776330-85-9

[1-benzo[b]thiophen-2-yl-3-(2-S-carbamoyl-pyrrolidin-1-yl)-3-oxo-propyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In DMF (N,N-dimethyl-formamide) at 20℃; for 2.5h;100%
C22H24N2O5
869882-73-5

C22H24N2O5

L-proline
147-85-3

L-proline

C27H33N3O7

C27H33N3O7

Conditions
ConditionsYield
In dichloromethane at 20℃; for 18h;100%
6-methyl-6-phenylfulvene
2320-32-3

6-methyl-6-phenylfulvene

L-proline
147-85-3

L-proline

A

salt of L-proline+6-methyyl-6-phenylfulvene

salt of L-proline+6-methyyl-6-phenylfulvene

B

α-phenethylcyclopentadiene

α-phenethylcyclopentadiene

Conditions
ConditionsYield
With n-butyllithiumA 100%
B n/a
L-proline
147-85-3

L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol at 20℃;100%
With sulfuryl dichloride; trimethyl orthoformate In methanol
With sulfuryl dichloride; trimethyl orthoformate In methanol
With sulfuryl dichloride; trimethyl orthoformate In methanol
di(μ-chloro)bis[1-(phenylazo)phenyl-C(2)N]dipalladium(II)
14873-53-1

di(μ-chloro)bis[1-(phenylazo)phenyl-C(2)N]dipalladium(II)

L-proline
147-85-3

L-proline

Pd(C6H4NNC6H5)(NHC4H7CO2)

Pd(C6H4NNC6H5)(NHC4H7CO2)

Conditions
ConditionsYield
With NaOMe In methanol N2-atmosphere; dropwise addn. of 1 equiv. NaOMe to aminoacid, gentle heating to dissoln., addn. of stoich. amt. Pd-complex, stirring for 15 h; solvent removal (vac.), dissoln. in CH2Cl2, centrifugation, solvent removal (vac.), repeated recrystn. (CH2Cl2/hexane); elem. anal.;100%
1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

L-proline
147-85-3

L-proline

1-(3-oxocyclohex-1-enyl)pyrrolidine-2-carboxylic acid
1033193-52-0

1-(3-oxocyclohex-1-enyl)pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
In benzene for 5h; Reflux;100%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

L-proline
147-85-3

L-proline

benzyl alcohol
100-51-6

benzyl alcohol

L‑proline benzyl ester p‑toluenesulfonate
32302-87-7

L‑proline benzyl ester p‑toluenesulfonate

Conditions
ConditionsYield
In tetrachloromethane for 24h; Reflux;100%
In cyclohexane for 4h; Solvent; Fischer-Speier Esterification; Reflux; Dean-Stark;100%

147-85-3Related news

Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of l-prolyl-l-leucyl-glycinamide (PLG) modified in the L-Proline (cas 147-85-3) or L-Proline (cas 147-85-3) and l-leucine scaffolds09/29/2019

Novel analogs of l-prolyl-l-leucylglycinamide (PLG) were synthesized wherein the prolyl residue was replaced with other amino acids based on a 3,5-disubstituted proline scaffold. In some examples, the l-leucyl residue was also replaced by l-valine. These analogs were tested for their ability to ...detailed

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