160754-06-3Relevant articles and documents
Process and intermediate to prepare N-alkyl-3,4-dialkyl-2,6-dinitro-anilines
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, (2008/06/13)
The intermediate STR1 wherein R is a lower alkyl group, is used to prepare a N-alkyl-3,4-dialkyl-2,6,-dinitro-aniline in a relatively simple, inexpensive and safe fashion, and with a high yield.
Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines
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, (2008/06/13)
A process is provided for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines of the formula Wherein R1 is hydrogen, C1 to C6 straight or branched chain alkyl group; and, R2, R3 and R4 are independently C1 to C6 straight or branched chain alkyl group optionally substituted by one or more halogen groups, wherein a. 3,4-dialkyl phenol of the formula is selectively nitrated with nitric acid in a two phase system to form 3,4-dialkyl-2,6-dinitrophenol of the formula: b. the 3,4-dialkyl-2,6-dinitrophenol is alkylated with an alkylating agent in the presence of a base and a catalytic amount of a phase transfer catalyst chosen from the group consisting of, , (R')4Q X-, , wherein R' may be the same or different C1 to C16 straight or branched alkyl groups, benzyl, substituted benzyl; Qis N or P; and Xis CL, Br, I or HSO4; a macrocyclic ether and polyethylene glycols of formula, , HO - (CH2CH2O-)n-CH2CH2OH, , where n is an integer from 10 to 50, in an organic solvent to form 3,4-dalkyl-2,6-dinitro alkoxybenzene of the formula: where R5 is an alkyl group having 1 to 6 carbon atoms. c. the 3,4-dialkyl-2,6-dinitro alkoxybenzene is reacted with an amine of the formula where R1 and R2 are defined above, in the presence of a catalytic amount of base or halide to form N-alkyl-3,4-dialkyl-2,6-dinitroaniline. d. the N-alkyl-3,4-dialkyl-2,6-dinitroaniline is recovered.