- Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties
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Quercetin derivatives are widespread in the plant kingdom and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of quercetin derivatives, with a focus on the influence of functional groups and sugar composition on their antioxidant capacity. A series of quercetin derivatives were therefore prepared and assessed for their DPPH radical scavenging properties. Isoquercetin O-gallates were more potent radical scavengers than quercetin. The systematic analysis highlights the importance of the distribution of hydroxy substituents in isoquercetin O-gallates to their potency.
- Kato, Komei,Ninomiya, Masayuki,Tanaka, Kaori,Koketsu, Mamoru
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supporting information
p. 1808 - 1814
(2016/08/02)
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- NOVEL FLAVANONE DERIVATIVE
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Provided is a novel antimicrobial agent. More specifically, provided is a novel antimicrobial agent capable of effectively acting on various resistant bacteria such as VSSA, MRSA, VISA, VRE, and VRSA. A novel flavanone derivative having a six-membered monosaccharide derivative, specifically, a glucose derivative or a galactose derivative is capable of effectively acting on the bacteria. More specifically, a compound represented by the general formula (I) is capable of effectively acting on the bacteria. (In the formula: X represents a six-membered monosaccharide derivative; and Y is substituted by a hydroxyl group.)
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Page/Page column 31
(2012/06/18)
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- Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents
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A structure-guided molecular design approach was used to optimize quercetin diacylglycoside analogues that inhibit bacterial DNA gyrase and topoisomerase IV and show potent antibacterial activity against a wide spectrum of relevant pathogens responsible f
- Hossion, Abugafar M. L.,Zamami, Yoshito,Kandahary, Rafiya K.,Tsuchiya, Tomofusa,Ogawa, Wakano,Iwado, Akimasa,Sasaki, Kenji
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p. 3686 - 3703
(2011/08/03)
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- Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure-activity relationship studies reveal salient pharmacophore features
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The 3C-like protease (3CLpro) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one of the most promising targets for discovery of drugs against SARS, because of its critical role in the viral life cycle. In this study,
- Chen, Lili,Li, Jian,Luo, Cheng,Liu, Hong,Xu, Weijun,Chen, Gang,Liew, Oi Wah,Zhu, Weiliang,Puah, Chum Mok,Shen, Xu,Jiang, Hualiang
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p. 8295 - 8306
(2007/10/03)
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- Synthesis and biological evaluation of flavonoids as vasorelaxant agents
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Several 5,7-dihydroxyflavone and quercetin 3-O-glycosides have been synthesized and evaluated for vasorelaxant activity. A logP-activity relationship amongst flavonoids was suggested.
- Chen, Zhiwei,Hu, Yongzhou,Wu, Haohao,Jiang, Huidi
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p. 3949 - 3952
(2007/10/03)
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