161462-35-7Relevant articles and documents
Preparation method of isoxaflutole key intermediate
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Paragraph 0028; 0032-0033; 0035-0036; 0038-0039; 0041, (2021/06/23)
The invention relates to the field of pesticide chemistry, in particular to a preparation method of an isoxaflutole key intermediate. The preparation method comprises the steps of under the protection of inert gas, dissolving 1-(2-(methylthio)-4-(trifluoromethyl) phenyl) ethanone and cyclopropane formonitrile in an organic solvent, adding strong base, carrying out heat treatment reaction on the mixture, adding acidizing fluid to adjust the pH value to be neutral after the reaction is completed, separating out a water phase, and concentrating an organic phase to obtain an intermediate I; and dissolving the intermediate I in an organic solvent, adding water and strong acid, carrying out a heat treatment reaction, separating a water phase after the reaction is completed, and concentrating an organic phase to obtain the 1-cyclopropyl-3-(2-(methylthio)-4-(trifluoromethyl) phenyl) propyl-1, 3-diketone. The preparation method of the isoxaflutole key intermediate provided by the invention has the advantages of mild reaction, less generation of impurities and solid wastes, improvement of the yield and purity of the product, and reduction of the production cost, and is suitable for industrial production.
Production method of isoxaflutole
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, (2020/08/06)
The invention provides a production method of isoxaflutole. The production method comprises the following steps: S1, generating an intermediate I from p-bromobenzotrifluoride under the action of a mixed acid of concentrated sulfuric acid and concentrated
Preparation method of 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)propyl-1,3-dione
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Paragraph 0052; 0059-0061, (2019/07/04)
The invention provides a preparation method of 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)propyl-1,3-dione, and belongs to the technical field of organic synthesis. The preparation method comprises following steps: (1) mixing 2-nitro-4-trifluor
Isoxaflutole synthesis method
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Paragraph 0017-0019, (2017/10/07)
The invention discloses a isoxaflutole synthesis method, which comprises: obtaining 1-cyclopropyl-3-(2-methylthio-4-trifluoromethylphenyl)propyl-1,3-dione by using cyclopropyl methyl ketone and 2-methylthio-4-trifluoromethyl methylbenzoate as raw materials, oxidizing to obtain 1-cyclopropyl-3-(2-methylsulfonyl-4-trifluoromethylphenyl)propyl-1,3-dione, and carrying out a reaction on the 1-cyclopropyl-3-(2-methylsulfonyl-4-trifluoromethylphenyl)propyl-1,3-dione, triethyl orthoformate and hydroxylamine hydrochloride to obtain the isoxaflutole. The isoxaflutole synthesis method of the present invention has characteristics of high yield, mild reaction condition, short reaction route, and simple operation.
Preparation of C1-C5 alkyl esters of nitro or thioether substituted aromatic carboxylic acids
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Example 11, (2010/11/29)
Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: Additionally the invention relates to a method for preparing a
PROCESS FOR THE PREPARATION OF 1-ARYL-3-CYCLOPROPYL-1,3-PROPANEDIONES
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, (2008/06/13)
A process for preparing a compound of the formula: which comprises reacting a compound of the formula: wherein R1 is C1-6 straight- or branched-chain alkyl, with a compound of the formula: in an aprotic solvent in the presence of bas
Isoxazole derivatives and their use as herbicides
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, (2008/06/13)
Compounds of formula 1 wherein R1and R2are independently C1-C8alkyl, are suitable for use as herbicides.
