128403-22-5

Usage

Uses

Used in Pharmaceutical Research and Development:
2'-Nitro-4'-trifluoroMethylacetophenone is employed as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs. Its unique functional groups facilitate targeted chemical reactions that are essential in creating specific medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 2'-Nitro-4'-trifluoroMethylacetophenone is used as a precursor in the production of various agrochemicals. Its properties allow for the creation of compounds that can be used in pest control and crop protection, enhancing agricultural productivity.
Used in Organic Synthesis:
As a versatile reagent in organic chemistry, 2'-Nitro-4'-trifluoroMethylacetophenone is utilized in a range of organic synthesis processes. Its presence in these reactions can lead to the formation of complex organic compounds that are valuable in various chemical and industrial applications.
Used in the Synthesis of Other Organic Compounds:
2'-Nitro-4'-trifluoroMethylacetophenone also serves as an intermediate for the synthesis of other organic compounds, expanding its applications beyond the pharmaceutical and agrochemical sectors. Its role in these syntheses is crucial for producing a diverse array of chemical products.

Upstream product

• 193744-38-6 2-nitro-1-(1-nitroethyl)-4-trifluoromethylbenzene 
• 107-25-5 methoxyethene 
• 349-03-1 1-bromo-4-trifluoromethyl-2-nitrobenzene 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 37885-07-7 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone 
• 346-55-4 4-chloro-7-trifluoromethyl quinoline 
• 128403-23-6 N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide 
• 128403-24-7 N'-(2-Acetyl-5-trifluoromethyl-phenyl)-N,N-dimethyl-formamidine; hydrochloride 
• 161462-35-7 1-Cyclopropyl-3-(2-methylsulphenyl-4-trifluoromethyl-phenyl)propane-1,3-dione 
• 178462-92-5 2-methylthio 4-trifluoromethylacetophenone 

Relevant academic research and scientific papers

Production method of isoxaflutole

The invention provides a production method of isoxaflutole. The production method comprises the following steps: S1, generating an intermediate I from p-bromobenzotrifluoride under the action of a mixed acid of concentrated sulfuric acid and concentrated

N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES

Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.

Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives

Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.

PROCESS FOR THE PREPARATION OF THIOETHER-SUBSTITUTED AROMATIC KETONES

The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds.

Catalyst for oxidative NEF reaction using basic hydrogen peroxide

The preparation of carbonyl compounds by oxidizing a nitro functional group of an organic compound is described. Oxidation is accomplished under catalyzed oxidative Nef reaction conditions.

Process for the preparation of thioether-substituted aromatic ketones

The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds.

4 Benzoyl isoxazole derivatives

4-Benzoyl isoxazole derivatives of the formula I: wherein:, R represents alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, -CO2R3,-COR5,cyano,nitro, -CONR31R4 or a halogen atom;, R1 represents :-, hydrogen , alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl or optionally substituted cycloalkyl, R2 represents :-, halogen, R5, -SR5, -SOR5, -SO2R5, -SO2NR31R4,-CO2R3, -COR5, -CONR31R4, -CSNR31R4, -OR5, a nitro group, a cyano group, a group -O(CH2)q-OR5 or alkyl substituted by OR5;, R3, R31 and R4, which may be the same or different, each represents:-, hydrogen, alkyl or haloalkyl;, R5 represents alkyl or haloalkyl;, n represents an integer from 1 to 5; and, q represents an integer from 1 to 3;, and agriculturally acceptable salts thereof and their use as herbicides is described.

Addition of nitroalkanes toortho-halonitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline

Base-mediated reaction of ortho-nitroaryl chlorides and fluorides with nitroalkanes followed by an oxidative Nef reaction provides aryl ketones. With this simple procedure, methylketone 6 was prepared in 91% yield. 6 was then converted in three steps (60-65% yield) to 4-chloro-7-(trifluoromethyl)quinoline (2), an intermediate in the synthesis of the antihypertensive agent losulazine (U-54,669, 1).