N1'-(p-[18F]fluorobenzyl)naltrindole (p-[18F]BNTI) as a potential PET imaging agent for DOP receptors
The N1'-(p-fluorobenzyl)naltrindole 5 has been synthesized by reaction of 3-O-benzyl NTI 3 with p-fluorobenzylbromide under phase transfer catalysis. The subsequent 3-O-benzyldeprotection of 4 in HBr/CH3COOH gave the target compound 5 in three
Akguen, Eyup,Sajjad, Munawwar,Portoghese, Philip S.
p. 857 - 866
(2008/02/09)
Delta opioid binding selectivity of 3-ether analogs of naltrindole
Masking of the 3-phenol of naltrindole as a range of ethers caused a decrease in binding affinity at all three opiate receptors (μ, κ, δ), however for the methyl ether, the reduction in affinity at both μ and κ was greater than at δ, thereby increasing δ
Coop, Andrew,Pinto, Julia,Wang, Lijuan,McCullough, Karen,Rothman, Richard B.,Dersch, Christine,Jacobson, Arthur E.,Rice, Kenner C.
p. 3435 - 3438
(2007/10/03)
SYNTHESIS OF N1'-(METHYL)NALTRINDOLE (MeNTI): A RADIOLIGAND FOR POSITRON EMISSION TOMOGRAPHIC STUDIES OF DELTA OPIOID RECEPTORS
A delta opioid receptor antagonist, N1'-methylnaltrindole (MeNTI), has been labeled with carbon-11.The precursor for radiolabeling was prepared in 71percent yield by benzylation of the phenolic moiety of naltrindole.Alkylation of the indole nitrogen using
Lever, John R.,Kinter, Chris M.,Ravert, Hayden T.,Musachio, John L.,Mathews, William B.,Dannals, Robert F.
p. 137 - 146
(2007/10/02)
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