161532-22-5Relevant academic research and scientific papers
N1'-(p-[18F]fluorobenzyl)naltrindole (p-[18F]BNTI) as a potential PET imaging agent for DOP receptors
Akguen, Eyup,Sajjad, Munawwar,Portoghese, Philip S.
, p. 857 - 866 (2008/02/09)
The N1'-(p-fluorobenzyl)naltrindole 5 has been synthesized by reaction of 3-O-benzyl NTI 3 with p-fluorobenzylbromide under phase transfer catalysis. The subsequent 3-O-benzyldeprotection of 4 in HBr/CH3COOH gave the target compound 5 in three
Delta opioid binding selectivity of 3-ether analogs of naltrindole
Coop, Andrew,Pinto, Julia,Wang, Lijuan,McCullough, Karen,Rothman, Richard B.,Dersch, Christine,Jacobson, Arthur E.,Rice, Kenner C.
, p. 3435 - 3438 (2007/10/03)
Masking of the 3-phenol of naltrindole as a range of ethers caused a decrease in binding affinity at all three opiate receptors (μ, κ, δ), however for the methyl ether, the reduction in affinity at both μ and κ was greater than at δ, thereby increasing δ
SYNTHESIS OF N1'-(METHYL)NALTRINDOLE (MeNTI): A RADIOLIGAND FOR POSITRON EMISSION TOMOGRAPHIC STUDIES OF DELTA OPIOID RECEPTORS
Lever, John R.,Kinter, Chris M.,Ravert, Hayden T.,Musachio, John L.,Mathews, William B.,Dannals, Robert F.
, p. 137 - 146 (2007/10/02)
A delta opioid receptor antagonist, N1'-methylnaltrindole (MeNTI), has been labeled with carbon-11.The precursor for radiolabeling was prepared in 71percent yield by benzylation of the phenolic moiety of naltrindole.Alkylation of the indole nitrogen using
