Resolution of cis-2-fluorocyclopropanecarboxylic acid by a microbial enantioselective hydrolysis
The important key intermediate of quinolone analogue synthesis, (1S,2S)- 2-fluorocyclopropanecarboxylic acid, was prepared enantioselectively by a microbial resolution. One of the strains with the highest enzymatic specificity was selected from soil and when lyophilized cells were treated with corresponding ester, the remaining (1S,2S)-ester was obtained with high enantiomeric purity (98% e.e.).
Imura, Akihiro,Itoh, Motohiro,Miyadera, Akihiko
p. 3047 - 3052
(2007/10/03)
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