161596-63-0

Basic information

• Product Name: (2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLIC ACID
• Synonyms: (2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLIC ACID;(2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLIC ACID 98%;2,4-Azetidinedicarboxylicacid,(2R,4R)-(9CI);(2R,4R)-(+)-Azetidine-2,4-dicarboxylic acid,98%
• CAS NO: 161596-63-0
• Molecular Formula: C5H7NO4
• Molecular Weight: 145.11
• Product Categories: CARBOXYLICACID
• Mol File: 161596-63-0.mol

Chemical Properties

• Boiling Point: 264.2°C (rough estimate)
• Appearance: /
• Density: 1.5047 (rough estimate)
• Refractive Index: 1.4320 (estimate)
• Storage Temp.: 0-6°C
• PKA: 1.73±0.40(Predicted)
• CAS DataBase Reference: (2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLIC ACID(161596-63-0)
• EPA Substance Registry System: (2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLIC ACID(161596-63-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 161596-63-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(2R,4R)-(+)-Azetidine-2,4-dicarboxylic acid is used as a research compound for studying the function and modulation of metabotropic glutamate (mGlu) receptor subtypes. Its unique structure allows it to interact with these receptors, providing insights into their role in various physiological processes and potential therapeutic applications.
Used in Chemical Synthesis:
(2R,4R)-(+)-Azetidine-2,4-dicarboxylic acid can be used as a building block or intermediate in the synthesis of more complex molecules, particularly those with potential pharmaceutical or biological activity. Its chiral nature and functional groups make it a versatile starting material for the development of novel compounds.
Used in Analytical Chemistry:
The compound can also be employed in analytical chemistry as a reference material or standard for the development and validation of analytical methods, such as chiral chromatography or mass spectrometry, which are used to separate and identify enantiomers and other stereoisomers.

Upstream product

• 3479-80-9 α,α'-dibromoglutaric acid 
• 121050-01-9 2,4-dibromoglutaric acid dibenzyl ester 
• 121049-90-9 trans-1-benzylazetidine-2,4-dicarboxylic acid dimethyl ester 
• 168753-31-9 dimethyl 1-<(S)-1-phenylethyl>azetidine-2,4-dicarboxylate 
• 168647-92-5 dimethyl 1-<(S)-1-phenylethyl>azetidine-2,4-dicarboxylate 
• 121050-02-0 (±)-trans-dibenzyl 2,2'-(1-benzylazetidine-2,4-diyl)diacetate 
• 121050-10-0 (2S,4R)-1-Benzyl-4-methylselanylcarbonyl-azetidine-2-carboxylic acid benzyl ester 
• 121050-02-0 cis-1-benzylazetidine-2,4-dicarboxylic acid dibenzyl ester 

Relevant articles and documents

Synthesis of optically active azetidine-2,4-dicarboxylic acid and related chiral auxiliaries for asymmetric synthesis

(S)-1-Phenylethylamine has been used as a chiral auxiliary as well as a nitrogen atom donor in the synthesis of an enantiomeric pair of azetidine-2,4-dicarboxylic acids, the absolute configuration of one of which has been assigned on the basis of the X-ra

Azetidine derivatives to treat memory and learning disorders

This invention relates to novel azetidines and derivatives thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and composi

Synthesis and Bioactivity of a New Class of Rigid Glutamate Analogues. Modulators of the N-Methyl-D-aspartate Receptor

A variety of derivatives of azetidine-2,4-dicarboxylic acid were synthesized and examined for their ability to stimulate 45Ca2+ uptake in cultures of cerebellar granule cells.Of the compounds tested, the cis-azetidine-2,4-dicarboxylic acid (10f

Azetidine derivatives, compositions and methods of treating

This invention relates to novel azetidines and derivative thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.