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CAS

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1616294-18-8

2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxy-phenyl)-piperidin-1-yl]-quinazoline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1616294-18-8 Structure

  • Basic information

    1. Product Name: 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxy-phenyl)-piperidin-1-yl]-quinazoline
    2. Synonyms: 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxy-phenyl)-piperidin-1-yl]-quinazoline
    3. CAS NO:1616294-18-8
    4. Molecular Formula:
    5. Molecular Weight: 419.524
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1616294-18-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxy-phenyl)-piperidin-1-yl]-quinazoline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxy-phenyl)-piperidin-1-yl]-quinazoline(1616294-18-8)
    11. EPA Substance Registry System: 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxy-phenyl)-piperidin-1-yl]-quinazoline(1616294-18-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1616294-18-8(Hazardous Substances Data)

1616294-18-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1616294-18-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,6,2,9 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1616294-18:
(9*1)+(8*6)+(7*1)+(6*6)+(5*2)+(4*9)+(3*4)+(2*1)+(1*8)=168
168 % 10 = 8
So 1616294-18-8 is a valid CAS Registry Number.

1616294-18-8Downstream Products

1616294-18-8Relevant articles and documents

Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Pinkerton, Anthony B.,Peddibhotla, Satyamaheshwar,Yamamoto, Fusayo,Slosky, Lauren M.,Bai, Yushi,Maloney, Patrick,Hershberger, Paul,Hedrick, Michael P.,Falter, Bekhi,Ardecky, Robert J.,Smith, Layton H.,Chung, Thomas D. Y.,Jackson, Michael R.,Caron, Marc G.,Barak, Lawrence S.

supporting information, p. 8357 - 8363 (2019/09/10)

Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders, but despite extensive efforts to develop small molecule ligands there are few reports of such compounds. Herein we describe the optimization of a quinazoline based lead to give 18 (SBI-553), a potent and brain penetrant NTR1 allosteric modulator.

SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1

-

, (2014/07/08)

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

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