- Tropsch process for cloth intermediate impurity, tofa for cloth impurity and its synthesis method, and Tropsch process for the cloth quality monitoring method
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The invention provides a tofacitinib intermediate impurity, tofacitinib impurity and a synthetic method, and a tofacitinib quality monitoring method. The tofacitinib intermediate impurity has a chemical formula in a formula (I), and the tofacitinib impurity has a chemical formula in a formula (II). Through the provided tofacitinib intermediate impurity and the tofacitinib impurity, the invention provides a standard contrast product for monitoring and optimizing quality of N-methyl-N-((3R,4R)-4-methyl piperidine-3-group)-7H-pyrrolo[2,3-D]pyrimidine-4-amine (tofacitinib), and then performs qualitative and quantitative analysis on the tofacitinib intermediate and tofacitinib.
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Paragraph 0044-0046; 0049; 0052; 0054
(2017/08/26)
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- THE PRESENT INVENTION RELATES TO PROCESS FOR THE PREPARATION OF TOFACITINIB AND INTERMEDIATES THEREOF.
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The present invention relates to process for the preparation of tofacitinib and intermediates thereof.
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Paragraph 0284
(2014/07/21)
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