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161689-53-8

2-amino-4-(2-furyl)-6-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3,5-dicarbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 161689-53-8 Structure

  • Basic information

    1. Product Name: 2-amino-4-(2-furyl)-6-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3,5-dicarbonitrile
    2. Synonyms: 2-amino-4-(2-furyl)-6-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3,5-dicarbonitrile
    3. CAS NO:161689-53-8
    4. Molecular Formula: C19H12N4O2S
    5. Molecular Weight: 360.38918
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 161689-53-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-amino-4-(2-furyl)-6-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3,5-dicarbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-amino-4-(2-furyl)-6-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3,5-dicarbonitrile(161689-53-8)
    11. EPA Substance Registry System: 2-amino-4-(2-furyl)-6-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3,5-dicarbonitrile(161689-53-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 161689-53-8(Hazardous Substances Data)

161689-53-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 161689-53-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,6,8 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 161689-53:
(8*1)+(7*6)+(6*1)+(5*6)+(4*8)+(3*9)+(2*5)+(1*3)=158
158 % 10 = 8
So 161689-53-8 is a valid CAS Registry Number.

161689-53-8Downstream Products

161689-53-8Relevant articles and documents

Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity

Betti, Marco,Catarzi, Daniela,Varano, Flavia,Falsini, Matteo,Varani, Katia,Vincenzi, Fabrizio,Pasquini, Silvia,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Lucarini, Elena,Dal Ben, Diego,Spinaci, Andrea,Bartolucci, Gianluca,Menicatti, Marta,Colotta, Vittoria

, p. 6894 - 6912 (2019)

A new series of amino-3,5-dicyanopyridines (1-31) was synthesized and biologically evaluated in order to further investigate the potential of this scaffold to obtain adenosine receptor (AR) ligands. In general, the modifications performed have led to comp

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics

May, Barnaby C. H.,Zorn, Julie A.,Witkop, Juanita,Sherrill, John,Wallace, Andrew C.,Legname, Giuseppe,Prusiner, Stanley B.,Cohen, Fred E.

, p. 65 - 73 (2007/10/03)

2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.

CYCLIZATION REACTIONS OF NITRILES. LIV. SYNTHESIS AND PROPERTIES OF 6-AMINO-4-ARYL-3,5-DICYANOPYRIDIN-2(1H)-ONES, THE CORRESPONDING THIONES, THE PYRIDYLIDENEMALONONITRILES, AND THEIR HYDROGENATED ANALOGS

Sharanin, Yu. A.,Krivokolysko, S. G.,Dyachenko, V. D.

, p. 620 - 626 (2007/10/02)

The reactions of arylmethylenecyanothioacetamides with cyanoacetamide, cyanothioacetamide, and the malononitrile dimer in the presence of N-methylmorpholine lead to the formation of substituted 1,4-dihydropyridyn-2-olates, 1,4-dihydropyridine-2-thiolates, and N-methylmorpholinium dicyanomethanides.During acidification 1,4-dihydropyridine-2-thiolates give 3,4-dihydropyridine- and pyridine-2(1H)-thiones.The latter were used in the synthesis of alkylthiopyridines and 1,4-dihydropyridines and also the corresponding thienopyridines and thiazolopyridinium triiodide.

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