123518-00-3

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 3237-22-7 2-cyano-3-(2-furanyl)acrylonitrile 
• 98-01-1 furfural 
• 109-77-3 malononitrile 

Downstream Products

• 161689-53-8 2-amino-4-(furan-2-yl)-6-((2-oxo-2-phenylethyl)sulfanyl)pyridine-3,5-dicarbonitrile 
• 918901-53-8 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile 
• 189278-42-0 2-amino-6-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-4-furan-2-yl-pyridine-3,5-dicarbonitrile 
• 161689-52-7 2-amino-6-[2-oxo-2-(4-chlorophenyl)ethylthio]-4-(furan-2-yl)pyridine-3,5-dicarbonitrile 
• 918901-42-5 2-amino-6-(2-oxo-2-(4-methoxyphenyl)ethylthio)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile 
• 1029220-75-4 3-benzyl-8-(2-furyl)-6-thioxo-1,3,4,6-tetrahydro-2H-pyrido[1,2-a][1,3,5]triazine-7,9-dicarbonitrile 

Relevant academic research and scientific papers

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics

2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.

NOVEL HETEROCYCLIC COMPOUNDS AS IKK2 INHIBITORS WITH ANTI-HBV ACTIVITY

This application relates to novel thienopyridines of Formula (I), which are IKK inhibitors and are useful for treating Hepatitis B infection and other diseases. This application also relates to pharmaceutical compositions comprising thienopyridines and the use of such compositions to treat Hepatitis B and other diseases.

CYCLIZATION OF NITRILES. XXX. SYNTHESIS, STRUCTURE, AND PROPERTIES OF 6-AMINO-4-ARYL(HETEROARYL)-3,5-DICYANO-2(1H)-PYRIDINETHIONES

The reactions of arylmethylenecyanothioacetamides with malononitrile and of arylmethylenemalononitriles with cyanothioacetamide take place regioselectively with the formation of 6-amino-4-aryl-3,5-dicyano-2(1H)-pyridinethiones and not 5-arylmethylene-4,6-diamino-3-cyanopyridine-2-thiones.The 6-amino-4-aryl-3,5-dicyano-2(1H)-pyridinethiones are formed by the recyclization of the 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyranes.