- Fe-Catalyzed enaminone synthesis from ketones and amines
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We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions.
- Wu, Wenfeng,Wang, Zhuxian,Shen, Qun,Liu, Qiang,Chen, Huoji
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supporting information
p. 6753 - 6756
(2019/07/22)
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- Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis
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An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).
- Wang, Tianzhang,Chen, Guowei,Lu, Yu-Jing,Chen, Qian,Huo, Yanping,Li, Xianwei
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supporting information
p. 3886 - 3892
(2019/07/19)
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- Nano-SiO2 catalyzed synthesis of β-enaminones under solvent free conditions
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Nano-SiO2 efficiently catalyzed the synthesis of β-enaminones using direct condensation of various (cyclic and acyclic) β-diketones with aromatic and aliphatic amines under solvent-free conditions. This eco-friendly catalyst can be recovered and reused without significant loss of activity. This methodology provides a simple synthetic route to enaminones in excellent yields at room temperature. Graphical abstract: [Figure not available: see fulltext.]
- Alinezhad, Heshmatollah,Tajbakhsh, Mahmood,Sarkati, Malihe Norouzi,Zare, Mahboobe
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p. 1591 - 1596
(2016/08/16)
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- FUSED QUINONIC COMPOUNDS
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A compound having the formula (I), for use in treating a disease; a composition comprising said fused quinonic compound of formula (I) and at least one pharmaceutically acceptable carrier; as well as a method of modulating a Janus Kinase-Signal Transducti
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Page/Page column 54
(2014/02/16)
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- Fused quinonic compounds
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A compound having the formula (I): for use in treating disease; a composition comprising said fused quinonic compound of formula (I) and at least one pharmaceutically acceptable carrier; as well as a method of modulating a Janus Kinase-Signal Transduction
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Paragraph 0155; 0156
(2014/02/15)
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- Microwave-assisted synthesis of chiral nopinane-annelated pyridines by condensation of pinocarvone oxime with enamines promoted by FeCl3 and CuCl2
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Reaction of pinocarvone oxime with enamines and FeCl3 or CuCl2 resulted in annulation of nopinane carbon frame with pyridine and regioselective formation of chiral nopinane-annelated pyridines in 20-39% yields. Chemical structure of the pyridine derivatives were proved by precise NMR study.
- Vasilyev, Eugene S.,Agafontsev, Alexander M.,Tkachev, Alexey V.
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p. 1817 - 1824
(2014/06/09)
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- Reaction of arynes with vinylogous amides: Nucleophilic addition to the ortho-quinodimethide intermediate
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The reaction of arynes with vinylogous amides containing no free N-H bonds proceeds in a [2 + 2] cycloaddition fashion at ambient temperature. The electronic properties of the vinylogous amides allow for the cycloadducts undergoing a facile ring-opening p
- Li, Ran,Wang, Xuemei,Wei, Zhibin,Wu, Chunrui,Shi, Feng
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supporting information
p. 4366 - 4369
(2013/09/24)
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- Ytterbium triflate catalyzed synthesis of β-enaminones
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β-Enaminones have been synthesized in very good yield under solvent-free conditions from differently substituted amines and β-diketones in the presence of Yb(OTf)3 as catalyst. The method is applicable to cyclic and acyclic ketones, aromatic an
- Epifano, Francesco,Genovese, Salvatore,Curini, Massimo
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p. 2717 - 2720
(2008/02/03)
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- Acid catalysed reactions of 5-formyluracils with enamines. A facile synthesis of 5-acylvinyluracils
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5-Formyl-1,3-dimethyluracil (1) reacts with secondary amine derived enamines of ketones and aldehydes to provide 5-(acyvinyl)uracil derivatives. The presence of a CH3 group at C-6 of 1 induces a competitive annulation reaction. Depending on the bulk of substituents 5-(acylvinyl)-uracils acquire cis -diene and E or Z configurations on the vinyl unit. Enamines derived from 1,3-cyclohexanedione and ethyl acetoacetate react with 1 in 1: 2 stoichiometric manner to provide 5-(9-xanthenyl)uracil and 5-(6- cycohexadienyl)uracil (X-ray) derivatives.
- Singh, Harjit,Dolly,Hundal, Maninder Singh,Hundal, Geeta,Singh, Palwinder,Chimni, Swapandeep Singh,Kumar, Subodh
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p. 7563 - 7572
(2007/10/03)
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- Addition reactions of cyclic s-trans-enaminones with Grignard reagents
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Addition of Grignard reagents to s-transenaminones derived from 1,3-cycloalkanediones are described. In dichloromethane, addition of phenylmagnesium bromide gave 3-phenyl substituted cycloalkenones. Alkylmagnesium halides underwent multiple addition reactions, giving mixtures of the 3-alkylcycloalkenones and 1,3-dialkyl-3-(dialkylamino)cyclohexenes. In tetrahydrofuran, only the 3-alkylcycloalkenone was obtained.
- Shawe, Thomas T.,Hansen, Darren B.,Peet, Kelly Ann,Prokopowicz, Anthony S.,Robinson, Patrice M.,Cannon, Annatina,Dougherty, Kathleen E.,Ross, Andrew A.,Landino, Linda M.
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p. 1547 - 1556
(2007/10/03)
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- 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones
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This invention relates to 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols of the formula STR1 wherein X is STR2 or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy, trifluoromethyl, nitro or amino; R is H when the bond between the oxy
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- 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, compositions and pharmaceutical use
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This invention relates to 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols of the formula STR1 wherein X is (Y) STR2 or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy, trifluoromethyl, nitro or amino; R is H when the bond between the
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