16179-67-2

Upstream product

• 110-91-8 morpholine 
• 108-94-1 cyclohexanone 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 61834-41-1 3-Phenyl-4-oxo-4,5,6,7-tetrahydrobenz[1,2-d]isoxazole 
• 55898-75-4 N-(6-oxo-2-morpholin-4-yl-cyclohex-1-enyl)-hydrazine-N,N'-dicarboxylic acid diethyl ester 
• 61834-40-0 3-methyl-6,7-dihydro-5H-benzo[d]isoxazol-4-one 
• 70989-98-9 Ethyl-[2-(morpholin-4-yl)-6-oxocyclohex-1-en-1-yl]carbonat 
• 70990-00-0 2-benzyloxycarbonyloxy-3-morpholin-4-yl-cyclohex-2-enone 
• 70989-96-7 2-benzoyloxy-3-morpholin-4-yl-cyclohex-2-enone 
• 70990-28-2 2-benzoyloxy-3-morpholin-4-yl-phenol 
• 70990-29-3 3-(morpholin-4-yl)benzene-1,2-diol 
• 70134-07-5 3-morpholin-4-yl-cyclohex-2-enethione 
• 40621-92-9 2-Hydroxy-3-(morpholin-4-yl)cyclohex-2-en-1-on 
• 105872-31-9 3-Hydroxy-2-methoxycyclohex-2-en-1-on 
• 105872-52-4 2-Methoxy-3-(morpholin-4-yl)cyclohex-2-en-1-on 
• 141949-80-6 3-(2-fluorophenyl)-6,7-dihydro-1,2-benzisoxazol-4(5H)-one 
• 27292-49-5 3-(4-morpholino)phenol 

Relevant academic research and scientific papers

Fe-Catalyzed enaminone synthesis from ketones and amines

We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions.

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Nano-SiO2 catalyzed synthesis of β-enaminones under solvent free conditions

Nano-SiO2 efficiently catalyzed the synthesis of β-enaminones using direct condensation of various (cyclic and acyclic) β-diketones with aromatic and aliphatic amines under solvent-free conditions. This eco-friendly catalyst can be recovered and reused without significant loss of activity. This methodology provides a simple synthetic route to enaminones in excellent yields at room temperature. Graphical abstract: [Figure not available: see fulltext.]

FUSED QUINONIC COMPOUNDS

A compound having the formula (I), for use in treating a disease; a composition comprising said fused quinonic compound of formula (I) and at least one pharmaceutically acceptable carrier; as well as a method of modulating a Janus Kinase-Signal Transducti

Fused quinonic compounds

A compound having the formula (I): for use in treating disease; a composition comprising said fused quinonic compound of formula (I) and at least one pharmaceutically acceptable carrier; as well as a method of modulating a Janus Kinase-Signal Transduction

Microwave-assisted synthesis of chiral nopinane-annelated pyridines by condensation of pinocarvone oxime with enamines promoted by FeCl3 and CuCl2

Reaction of pinocarvone oxime with enamines and FeCl3 or CuCl2 resulted in annulation of nopinane carbon frame with pyridine and regioselective formation of chiral nopinane-annelated pyridines in 20-39% yields. Chemical structure of the pyridine derivatives were proved by precise NMR study.

Reaction of arynes with vinylogous amides: Nucleophilic addition to the ortho-quinodimethide intermediate

The reaction of arynes with vinylogous amides containing no free N-H bonds proceeds in a [2 + 2] cycloaddition fashion at ambient temperature. The electronic properties of the vinylogous amides allow for the cycloadducts undergoing a facile ring-opening p

Ytterbium triflate catalyzed synthesis of β-enaminones

β-Enaminones have been synthesized in very good yield under solvent-free conditions from differently substituted amines and β-diketones in the presence of Yb(OTf)3 as catalyst. The method is applicable to cyclic and acyclic ketones, aromatic an

Acid catalysed reactions of 5-formyluracils with enamines. A facile synthesis of 5-acylvinyluracils

5-Formyl-1,3-dimethyluracil (1) reacts with secondary amine derived enamines of ketones and aldehydes to provide 5-(acyvinyl)uracil derivatives. The presence of a CH3 group at C-6 of 1 induces a competitive annulation reaction. Depending on the bulk of substituents 5-(acylvinyl)-uracils acquire cis -diene and E or Z configurations on the vinyl unit. Enamines derived from 1,3-cyclohexanedione and ethyl acetoacetate react with 1 in 1: 2 stoichiometric manner to provide 5-(9-xanthenyl)uracil and 5-(6- cycohexadienyl)uracil (X-ray) derivatives.

Addition reactions of cyclic s-trans-enaminones with Grignard reagents

Addition of Grignard reagents to s-transenaminones derived from 1,3-cycloalkanediones are described. In dichloromethane, addition of phenylmagnesium bromide gave 3-phenyl substituted cycloalkenones. Alkylmagnesium halides underwent multiple addition reactions, giving mixtures of the 3-alkylcycloalkenones and 1,3-dialkyl-3-(dialkylamino)cyclohexenes. In tetrahydrofuran, only the 3-alkylcycloalkenone was obtained.