161891-31-2

Basic information

• Product Name: (E)-3-(4-bromophenyl)-3-chloro-prop-2-enal
• CAS NO: 161891-31-2
• Molecular Formula: C₉H₆BrClO
• Molecular Weight: 245.5
• Mol File: 161891-31-2.mol

Chemical Properties

• Boiling Point: 328.2°C at 760 mmHg
• Flash Point: 152.3°C
• Density: 1.547g/cm³
• Vapor Pressure: 0.000192mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: (E)-3-(4-bromophenyl)-3-chloro-prop-2-enal(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-bromophenyl)-3-chloro-prop-2-enal(161891-31-2)
• EPA Substance Registry System: (E)-3-(4-bromophenyl)-3-chloro-prop-2-enal(161891-31-2)

Safety Data

• Hazardous Substances Data: 161891-31-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(E)-3-(4-bromophenyl)-3-chloro-prop-2-enal is utilized as a building block in the synthesis of other organic compounds, particularly those requiring the presence of a bromophenyl or chloro group. Its structural diversity makes it a valuable component in creating a wide range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (E)-3-(4-bromophenyl)-3-chloro-prop-2-enal serves as a starting material for the production of fine chemicals and pharmaceutical intermediates. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Biological and Pharmacological Research:
(E)-3-(4-bromophenyl)-3-chloro-prop-2-enal has been studied for its potential biological and pharmacological properties. Researchers are interested in exploring its interactions with biological systems and its possible use in the development of new therapeutic agents.

Upstream product

• 56587-87-2 (1E,2E)-1,2-bis(1-(4-bromophenyl)ethylidene)hydrazine 
• 68-12-2 N,N-dimethyl-formamide 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 1620397-65-0 (E)-3-(4-bromophenyl)-3-(methylthio)acrylaldehyde 

Relevant articles and documents

Synthesis of novel β-aryl-β-(methylthio)acroleins via Vilsmeier-Haack protocol as potential 1,3-dielectrophilic three-carbon building blocks

A new general route for the synthesis of novel β-aryl-β- (methylthio)acroleins, a class of stable potential 1,3-dielectrophilic synthons, has been reported. The overall protocol involves treatment of either β-chloroacroleins or their precursor iminium salts (generated in situ from the corresponding active methylene ketones under Vilsmeier-Haack reaction conditions) with S,S-dimethyldithiocarbonates (DDC)/aqueous KOH in either a one-pot or two-step process. The dimethyldithiocarbonate (DDC)/30% aqueous KOH has been shown to be an excellent source of methylthiolate anion.

Ring and side chain formylated pyrazoles from acetophenone azines and Vilsmeier's reagent

Differently substituted acetophenone azines on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have found to yield three products in each case. An acceptable mechanism has been suggested for the formation of all the three products.