One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis
One-pot syntheses of polysubstituted 3-acylpyrroles from readily available unsaturated ketones and N-substituted propargylated amines have been developed. An aza-Michael/alkyne carbocyclization cascade, by cooperative catalysis using pyrrolidine and a copper salt, followed by oxidation in situ gave 3-acylpyrroles, which were also transformed further to functionalized, highly substituted 3-acylpyrroles. This journal is the Partner Organisations 2014.
Cui, Hai-Lei,Tanaka, Fujie
p. 5822 - 5826
(2014/08/05)
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