Asymmetric aldol addition of α-azido ketones to ethyl pyruvate mediated by a cinchona-based bifunctional urea catalyst Dedicated to the memory of Prof. Dr. Ayhan S. Demir
The first asymmetric synthesis of ethyl 4-aryl-3-azido-2-hydroxy-2-methyl- 4-oxobutanoates via a cinchona organocatalyst induced aldol addition of α-azido ketones to ethyl pyruvate has been developed. The coupling reaction under optimized conditions was carried out to furnish tetrafunctionalized synthons with enantioselectivities of up to 91:9 and enriched diastereoselectivities of up to 95:5 (syn:anti).
Okumu?, Seda,Tanyeli, Cihangir,Demir, Ayhan S.
supporting information
p. 4302 - 4305
(2014/07/22)
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