Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation
A new click bioorthogonal reaction system was devised to enable the fast ligation (kON≈340 m-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates were found to form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 m-1). Efficient protein conjugation under physiological conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.
Akgun, Burcin,Hall, Dennis G.
supporting information
p. 3909 - 3913
(2016/03/19)
Compound having fluorinated naphthalene structure and liquid crystal composition of the same
There is provided a liquid crystal composition containing the compound represented by the general formula (1) and a liquid crystal display device that uses the liquid crystal composition. The compound represented by the general formula (1) has high Δ∈, hi
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Page/Page column 37
(2016/05/19)
COMPOUND HAVING FLUORINATED NAPHTHALENE STRUCTURE AND LIQUID CRYSTAL COMPOSITION OF SAID COMPOUND
There is provided a liquid crystal composition containing the compound represented by the general formula (1) and a liquid crystal display device that uses the liquid crystal composition. The compound represented by the general formula (1) has high Δ∈, high Tni, and good miscibility with other liquid crystal compounds. Therefore, a liquid crystal composition that has high Δ∈ and exhibits a liquid crystal phase in a wide temperature range can be obtained by using the compound represented by the general formula (1) as a component of the liquid crystal composition. Thus, the compound is very useful as a constituent component of the liquid crystal composition for liquid crystal display devices.
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Paragraph 0139-0141
(2016/10/10)
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