1621066-74-7

Basic information

• Product Name: (S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e.
• Synonyms: (S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e.
• CAS NO: 1621066-74-7
• Molecular Formula: C17H14Br2O2
• Molecular Weight: 410.09986
• Mol File: 1621066-74-7.mol

Chemical Properties

• Boiling Point: 449.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.91±0.1 g/cm3(Predicted)
• PKA: 8.03±0.20(Predicted)
• CAS DataBase Reference: (S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e.(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e.(1621066-74-7)
• EPA Substance Registry System: (S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e.(1621066-74-7)

Safety Data

• Hazardous Substances Data: 1621066-74-7(Hazardous Substances Data)

Usage

Uses

Used in Asymmetric Synthesis:
(S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e. is used as a chiral building block for asymmetric synthesis, enabling the creation of enantioselective reactions and the production of chiral compounds with specific biological activities.
Used in Chiral Ligands:
(S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e. is used as a chiral ligand in various chemical reactions, enhancing the selectivity and efficiency of enantioselective processes.
Used in Pharmaceutical Industry:
(S)-6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol,99%e.e. is used as a building block for drug development in the pharmaceutical industry, due to its high enantiomeric purity and unique structural features that can be utilized in the design of novel therapeutic agents.

Upstream product

• 223137-87-9 (R)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol 

Relevant articles and documents

Optically active 1,1′-Spirobiindane-7,7′-diol (SPINOL)-based phosphoric acids as highly enantioselective catalysts for asymmetric organocatalysis

The synthesis and application of a series of optically active 1,1′-spirobiindane-7,7′-diol (SPINOL)-based phosphoric acids are described. These SPINOL-based phosphoric acids were prepared from (R)-SPINOL in three steps and exhibited excellent enantioselec

Phosphoramidite gold(I)-catalyzed diastereo- and enantioselective synthesis of 3,4-substituted pyrrolidines

In this article the utility of phosphoramidite ligands in enantioselective AuI catalysis was explored in the development of highly diastereo- and enantioselective AuI-catalyzed cycloadditions of allenenes. A AuI-catalyzed synthesis of 3,4-disubstituted pyrrolidines and γ-lactams is described. This reaction proceeds through the enantioselective AuI-catalyzed cyclization of allenenes to form a carbocationic intermediate that is trapped by an exogenous nucleophile, resulting in the highly diastereoselective construction of three contiguous stereogenic centers. A computational study (DFT) was also performed to gain some insight into the underlying mechanisms of these cycloadditions. The utility of this new methodology was demonstrated through the formal synthesis of (-)-isocynometrine.(Figure Presented)