162502-44-5

Basic information

• Product Name: 3-Amino-4-fluoro-1-methylindazole
• Synonyms: 3-Amino-4-fluoro-1-methylindazole;4-Fluoro-1-methyl-1H-indazol-3-ylamine
• CAS NO: 162502-44-5
• Molecular Formula: C8H8FN3
• Molecular Weight: 165.17
• Mol File: 162502-44-5.mol

Chemical Properties

• Boiling Point: 325.2°C at 760 mmHg
• Flash Point: 150.5°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-Amino-4-fluoro-1-methylindazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-fluoro-1-methylindazole(162502-44-5)
• EPA Substance Registry System: 3-Amino-4-fluoro-1-methylindazole(162502-44-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 162502-44-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
3-Amino-4-fluoro-1-methylindazole is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it a valuable asset in the field of medicinal chemistry.
Used in Medicinal Chemistry:
As a building block in the synthesis of other compounds, 3-Amino-4-fluoro-1-methylindazole is employed in medicinal chemistry to create novel molecules with potential biological activity. Its presence in these compounds can influence their pharmacokinetic and pharmacodynamic properties, leading to the discovery of new therapeutic agents.
Used in Drug Discovery:
3-Amino-4-fluoro-1-methylindazole is of interest to researchers in the field of drug discovery due to its potential biological activity. Its unique structure and properties make it a promising candidate for the development of new drugs with improved efficacy and selectivity, contributing to the advancement of therapeutic options for various diseases and conditions.

InChI:InChI=1/C8H8FN3/c1-12-6-4-2-3-5(9)7(6)8(10)11-12/h2-4H,1H3,(H2,10,11)

Upstream product

• 1897-52-5 2,6 difluorobenzonitrile 
• 60-34-4 methylhydrazine 

Downstream Products

• 1092961-07-3 4-fluoro-1-methyl-1H-indazole 

Relevant articles and documents

A method for the regioselective synthesis of 1-alkyl-1H-indazoles

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles follo

N-aryl[1,2,4]triazolo[1,5-a]pyrazine-2-sulfonamide herbicides

Substituted N-aryl[1,2,4]triazolo[1,5-a]-pyrazine-2-sulfonamide compounds, such as 5-bromo-N-(2,6-dichlorophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]-pyrazine-2-sulfonamide, were prepared by condensation of a substituted 2-chlorosulfonyl[1,2,4]triazolo[1,5-a]pyrazine compound, such as 5-bromo-2-chlorosulfonyl-8-methoxy[1,2,4]triazolo[1,5-a]pyrazine with a substituted arylamine compound, such as 2,6-dichloroaniline, and found to possess herbicidal utility.

Ring annulated 5-alkoxy-n-aryl[1,2,4]triazolo[1,5-C]-pyrimidine-2-sulfonamide herbicides

Substituted ring annulated 5-alkoxy-N-aryl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide compounds, such as N-(2,6-dichlorophenyl)-5-methoxycyclopenteno[d]-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared by condensation of an appropriate 2-chloro-sulfonyl-5-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-5-methoxycyclopenteno[d][1,2,4]triazolo[1,5-c]pyrimidine, with a substituted arylamine compound, such as 2,6-dichloroaniline, and found to possess herbicidal utility.

N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides

Substituted N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide compounds, such as N-(2,6-difluorophenyl)-5-methoxy-7-methyl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide, N-(4-bromo-1-methyl-3-pyrazoly)-8-chloro-5-methoxy[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide, and N-(2-fluoro-4-methyl-3-pyridinyl)-8-ethoxy-6-chloro[1,2,4]triazolo[1,5-a]-pyridine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-a]pyridine compound with an aryl amine. The compounds prepared were found to possess excellent herbicidal activity on a broad spectrum of vegetation at low application rates.

N-indazolyl[1,2,4]triazolo[1,5-C]pyrimidine-2-sulfonamide herbicides

Substituted N-indazolyl[1,2,4]triazolo[1,5]-c-pyrimidine-2-sulfonamide compounds, such as N-(4-fluoro-1-methyl-3-indazolyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine, with a substituted 3-aminoindazole compound, such as 3-amino-4-fluoro-1-methylindazole, and found to possess herbicidal utility.