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H-D-Tyr(3-Cl)-OH, also known as 3-Chloro-L-tyrosine, is a synthetic amino acid derivative that is distinguished by the presence of a chlorine atom at the third position of its phenyl ring. This unique characteristic makes it a valuable compound in various scientific fields, particularly in proteomics, where it serves as a useful marker for specific biological processes.

162599-96-4

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162599-96-4 Usage

Uses

Used in Chemical and Biological Research:
H-D-Tyr(3-Cl)-OH is used as a research compound in the fields of chemistry and biology, where it aids in the study of proteomics and the investigation of protein structures and functions. Its distinctive chemical properties make it a valuable tool for understanding the roles of amino acids in biological systems.
Used as a Marker for Hypochlorous Acid (HOCl) and Myeloperoxidase (MPO) Activity:
In biological systems, H-D-Tyr(3-Cl)-OH is employed as a marker for hypochlorous acid (HOCl) and myeloperoxidase (MPO) activity. These markers are associated with inflammation, aging, and certain diseases, making H-D-Tyr(3-Cl)-OH an important indicator for monitoring and studying these physiological processes.
Synthesis:
Despite its relative complexity, H-D-Tyr(3-Cl)-OH can be effectively synthesized using various chemistry methods, making it accessible for research and potential applications in different scientific disciplines.

Check Digit Verification of cas no

The CAS Registry Mumber 162599-96-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,5,9 and 9 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 162599-96:
(8*1)+(7*6)+(6*2)+(5*5)+(4*9)+(3*9)+(2*9)+(1*6)=174
174 % 10 = 4
So 162599-96-4 is a valid CAS Registry Number.
InChI:InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

162599-96-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Chloro-L-tyrosine

1.2 Other means of identification

Product number -
Other names B-chloro-dl-alanine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162599-96-4 SDS

162599-96-4Relevant articles and documents

Synthesis and Biological Evaluation of Modified Miuraenamides

Kappler, Sarah,Karmann, Lisa,Prudel, Cynthia,Herrmann, Jennifer,Caddeu, Giulia,Müller, Rolf,Vollmar, Angelika M.,Zahler, Stefan,Kazmaier, Uli

, p. 6952 - 6965 (2018/11/25)

Miuraenamides, secondary metabolites of the marine myxobacterium Paraliomyxa miuraensis do not only show a high structural similarity to other cyclodepsipeptides isolated from sponges or terrestrial myxobacteria but they also exhibit a similar mode of act

Novel cryptophycin antitumor agents: Synthesis and cytotoxicity of fragment 'B' analogues

Patel, Vinod F.,Andis, Sherri L.,Kennedy, Joseph H.,Ray, James E.,Schultz, Richard M.

, p. 2588 - 2603 (2007/10/03)

A general synthetic approach to novel cryptophycin analogues 6 is described. N-Hydroxysuccinimide active ester 15, a key common intermediate, was converted to β-epoxide 6 in three steps, via initial coupling with unprotected amino acid 9, followed by deprotection/macrolactamization of acyclic precursor 16, and final oxidation of styrene 7 to install the C7-C8 β-epoxide. Cryptophycin styrenes 7 and β-epoxides 6, bearing diverse side chains in fragment 'B', were evaluated for cytotoxic activity, β-Epoxides 6, in general, were significantly more potent than the corresponding α-epoxides 17 and styrenes 7. A benzyl side chain was required for potent activity, with β-epoxide 6u, possessing a 3-Cl,4-(dimethylamino)benzyl moiety, as the most potent cytotoxic agent prepared, with an IC50 = 54 pM, only 2-fold-less than that of Cryptophycin-52 (3).

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