162648-46-6

Basic information

• Product Name: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID
• Synonyms: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID;1-PYRIMIDIN-4-YLMETHANAMINE
• CAS NO: 162648-46-6
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 162648-46-6.mol

Chemical Properties

• Boiling Point: 390.685 °C at 760 mmHg
• Flash Point: 190.08 °C
• Appearance: /
• Density: 1.196
• Vapor Pressure: 8.36E-07mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID(162648-46-6)
• EPA Substance Registry System: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID(162648-46-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 162648-46-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID is used as a potential anti-inflammatory agent for its ability to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID is also used as a potential treatment for neurodegenerative diseases due to its potential to target and mitigate the underlying causes of these conditions, offering a new avenue for therapeutic intervention.

InChI:InChI=1/C11H13NO2/c1-12-6-2-3-8-7-9(11(13)14)4-5-10(8)12/h4-5,7H,2-3,6H2,1H3,(H,13,14)

Upstream product

• 493-50-5 1-methyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde 
• 38896-30-9 6-(methoxycarbonyl)quinoline 
• 177478-49-8 methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate 
• 5382-49-0 1,2,3,4-tetrahydroquinoline-6-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 845877-81-8 1-methyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid [2-hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-amide 

Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models

During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resistant and multi-drug-resistant cancer cell lines, but its utility in vivo was limited by a short half-life. Medicinal chemistry efforts led to the discovery of indolyloxazoline 22g (A-259745), which maintained all of the in vitro activity seen with oxadiazoline 1, but also demonstrated a better pharmacokinetic profile, and dose-dependent in vivo activity. Over a 28 day study, indolyloxazoline 22g increased the life span of tumor-implanted mice by up to a factor of 3 upon oral dosing. This compound, and others of its structural class, may prove to be useful in the development of new chemotherapeutic agents to treat human cancers.

Heterocyclic esters of rapamycin

A compound of the structure STR1 wherein R and R1 are each, independently, STR2 or hydrogen, R2 is a heterocyclic radical which may be optionally substituted; n=0-6; with the proviso that R and R1 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.