5382-49-0Relevant articles and documents
PGDH INHIBITORS AND METHODS OF MAKING AND USING
-
Paragraph 0271; 0278; 0283; 0400-0401; 0438-0439, (2021/07/31)
Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.
Catalytic Hydrogenation of Substituted Quinolines on Co–Graphene Composites
Asaula, Vitalii M.,Buryanov, Volodymyr V.,Solod, Bohdan Y.,Tryus, Daryna M.,Pariiska, Olena O.,Kotenko, Igor E.,Volovenko, Yulian M.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Kolotilov, Sergey V.
, p. 6616 - 6625 (2021/12/24)
A set of 20 composites was prepared by pyrolysis of Co2+ complexes with 1,10-phenanthroline, melamine and 1,2-diaminobenzene. These composites were tested as the catalysts for the hydrogenation of quinolines. As shown by powder X-ray diffraction and TEM, the composited contained Co particles of several dozen nm sizes. The composition (elements content), Raman spectra X-ray photoelectron spectra parameters of the composites were analyzed. It was found that there was no distinct factor that controlled the yield of 1,2,3,4-tetrahydroquinolines in the investigated process. The yields of the respective products were in the range 90–100 %. The three most active composites were selected for scale-up and hydrogenation of a series of substituted quinolines. Up to 97 % yield of 1,2,3,4-tetrahydroquinoline was obtained on a 50 g scale. Five representative substituted quinolines were synthesized on a 10–20 grams scale using the Co-containing composites as the catalysts.
Simple manganese carbonyl catalyzed hydrogenation of quinolines and imines
Wang, Zelong,Chen, Lei,Mao, Guoliang,Wang, Congyang
, p. 1890 - 1894 (2020/03/04)
Manganese-catalyzed hydrogenation of unsaturated molecules has made tremendous progresses recently benefiting from non-innocent pincer or bidentate ligands for manganese. Herein, we describe the hydrogenation of quinolines and imines catalyzed by simple manganese carbonyls, Mn2(CO)10 or MnBr(CO)5, thus eliminating the prerequisite pincer-type or bidentate ligands.
