- Low-temperature continuous reactor and working method for producing diazo compounds
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The invention provides a low-temperature continuous reactor and a working method for producing diazo compounds. The low-temperature continuous reactor comprises two reaction bottles and an overflow kettle, the output end of a first reaction bottle is connected with the input end of a peristaltic pump, and the output end of a second reaction bottle is connected with the input end of a plunger pump;and the input end of the peristaltic pump and the input end of the plunger pump are connected with the overflow kettle in series. Arylamine is used as a starting raw material, a solvent is used for preparing a solution or a uniform mixture, the solution or the uniform mixture and a sodium nitrite solution are continuously fed in a small-volume overflow kettle reactor through a pump for an equivalent reaction, the reacted material is continuously introduced into an acetic acid solution of sulfur dioxide through an overflow pipeline, and through extraction and concentration, the product is obtained, and the total yield is up to 80% or above.
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Paragraph 0025-0028; 0038-0042
(2021/03/24)
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- Substituted Disulfonamide Compounds
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Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).
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Page/Page column 44
(2010/06/22)
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- Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
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The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
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- Compounds for the modulation of PPARgamma activity
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Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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- Sulfonyl chloride as a disposable electron withdrawing substituent in halex fluorinations
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Syntheses of 1,3-difluorobenzene and 2,6-difluorotoluene are described via chlorosulfonation, catalytic Halex-fluorination, and desulfination of 1,3-dichlorobenzene and 2,6-dichlorotoluene.
- Kageyama, Hiroyuki,Suzuki, Hiroshi,Kimura, Yoshikazu
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