162887-23-2

Basic information

• Product Name: 4-Bromo-1,2-pyrazolidinedicarboxaldehyde
• Synonyms: 4-Bromo-1,2-Pyrazolidinedicarboxaldehyde;4-BroMopyrazolidine-1,2-dicarbaldehyde
• CAS NO: 162887-23-2
• Molecular Formula: C5H7BrN2O2
• Molecular Weight: 207.03
• Product Categories: API intermediates;(intermediate of biapenem)
• Mol File: 162887-23-2.mol

Chemical Properties

• Melting Point: 83-84 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 273.4 °C at 760 mmHg
• Flash Point: 119.1 °C
• Appearance: /
• Density: 2.104 g/cm³
• Vapor Pressure: 0.00576mmHg at 25°C
• Refractive Index: 1.798
• PKA: -3.05±0.40(Predicted)
• CAS DataBase Reference: 4-Bromo-1,2-pyrazolidinedicarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1,2-pyrazolidinedicarboxaldehyde(162887-23-2)
• EPA Substance Registry System: 4-Bromo-1,2-pyrazolidinedicarboxaldehyde(162887-23-2)

Safety Data

• Hazardous Substances Data: 162887-23-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Bromo-1,2-pyrazolidinedicarboxaldehyde is used as a key intermediate for the synthesis of pharmaceutical products, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, 4-Bromo-1,2-pyrazolidinedicarboxaldehyde is employed as a building block for the creation of various agrochemicals, enhancing crop protection and yield.
Used in Fine Chemicals Preparation:
4-Bromo-1,2-pyrazolidinedicarboxaldehyde is utilized as a versatile component in the preparation of fine chemicals, which are essential in a wide range of applications, from fragrances to dyes.
Used in Heterocyclic Compounds Synthesis:
4-Bromo-1,2-pyrazolidinedicarboxaldehyde is used as a reagent in the synthesis of heterocyclic compounds, which are important in various chemical and pharmaceutical applications due to their unique properties and structures.
Used in Chemical Research:
4-Bromo-1,2-pyrazolidinedicarboxaldehyde is used as a research tool for studying the synthesis and properties of various chemical compounds, furthering scientific understanding and innovation in the field.
Used in Amino Acids and Peptides Detection:
As a reagent for the selective detection of amino acids and peptides, 4-Bromo-1,2-pyrazolidinedicarboxaldehyde plays a crucial role in biochemical analysis and the study of protein structure and function.

InChI:InChI=1/C5H7BrN2O2/c6-5-1-7(3-9)8(2-5)4-10/h3-5H,1-2H2

Upstream product

• 216854-54-5 1-(2,3-dibromopropyl)-1,2-diformylhydrazine 
• 216854-53-4 1-allyl-1,2-diformylhydrazine 

Downstream Products

• 216854-55-6 4-(acetylthio)-1,2-diformylpyrazolidine 

Relevant articles and documents

Biapenem side chain product V production process

The present invention relates to the field of medicine preparation, particularly to the field of biapenem side chains. According to the present invention, the ertapenem side chain belongs to a medicine preparation raw material, and can be used for producing ertapenem antibiotic drugs; ertapenem is a novel carbapenem-based antibiotic, and can be combined with penicillin-binding protein so as to interfere the synthesis of bacterial cell walls and cause the inhibition on bacterial growth and reproduction, wherein a small amount of cell lysis can be generated; and the product can provide high antibacterial activity on methicillin-sensitive Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and other Gram-positive bacteria, and Enterobacteriaceae bacteria, and is highly sensitive to Haemophilus, Moraxelle catarrhalis, Neisseria meningitidis and the like, and methicillin-resistant Staphylococcus, Enterococcus, Pseudomonas aeruginosa, Acinetobacter and other bacteria resist the product.

New straightforward synthesis and characterization of a unique 1β- methylcarbapenem antibiotic biapenem bearing a σ-symmetric bicyclotriazoliumthio group as the pendant moiety

Biapenem 1, (1R,5S,6S,)-2-[(6,7-dihydro-5H-pyrazolo[1,2- α][1,2,4]triazolium-6-yl)thio]-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1- methylcarbapen-2-em-3-carboxylate, is a new non-natural 1β-methylcarbapenem antibiotic which exhibits a wide range of antibacterial activity, remarkable chemical stability, and extensive stability against human renal dehydropeptidase-I. Mercaptobicyclotriazolium chloride 2 useful for the pendant moiety of 1 was successfully synthesized starting from hydrazine hydrate 3 along an economically available synthetic route. The thiol 2 was efficiently exploited for an expeditious synthesis of biapenem 1. Characterization (crystal structure, nonbonded S- - -O interaction, conformational analysis, and CH- - -O hydrogen bonds) of 1 was investigated by its X-ray crystallographic, 1H NMR, and deuteration experiment analyses.