- Organocatalyzed Fluoride Metathesis
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A new organocatalyzed fluoride metathesis reaction between fluoroarenes and carbonyl derivatives is reported. The reaction exchanges fluoride (F-) and alternate nucleophiles (OAc-, OCO2R-, SR-, Cl-, CN-, NCS-). The approach provides a conceptually novel route to manipulate the fluorine content of organic molecules. When the fluorination and defluorination steps are combined into a single catalytic cycle, a byproduct free and 100% atom-efficient reaction can be achieved.
- Mulryan, Daniel,White, Andrew J. P.,Crimmin, Mark R.
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supporting information
p. 9351 - 9355
(2020/11/30)
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