266312-20-3

Basic information

• Product Name: 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE
• Synonyms: 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE;4-Pyridinecarboxaldehyde,2,3,5-trifluoro-(9CI);2,3,5-trifluoro-4-pyridinecarboxaldehyde;2,3,5-Trichloropyrid;2,3,5-trifluoroisonicotinaldehyde
• CAS NO: 266312-20-3
• Molecular Formula: C6H2F3NO
• Molecular Weight: 161.08
• Product Categories: HALIDE
• Mol File: 266312-20-3.mol

Chemical Properties

• Boiling Point: 181.6 °C at 760 mmHg
• Flash Point: 63.6 °C
• Appearance: /
• Density: 1.506 g/cm³
• PKA: -7.27±0.28(Predicted)
• CAS DataBase Reference: 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE(266312-20-3)
• EPA Substance Registry System: 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE(266312-20-3)

Safety Data

• Hazardous Substances Data: 266312-20-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3,5-Trifluoropyridine-4-carboxaldehyde serves as a crucial building block in the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3,5-Trifluoropyridine-4-carboxaldehyde is utilized as a key intermediate in the production of pesticides and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness in controlling pests and diseases, thereby contributing to improved agricultural yields.
Used in Specialty Chemicals Industry:
2,3,5-Trifluoropyridine-4-carboxaldehyde is also employed in the synthesis of specialty chemicals, which are high-value products used in various applications such as coatings, adhesives, and advanced materials. Its unique properties allow for the creation of novel chemical entities with specific functionalities.
Used as a Reagent in Organic Synthesis:
2,3,5-Trifluoropyridine-4-carboxaldehyde functions as a versatile reagent in organic synthesis, enabling the formation of a wide range of chemical compounds. Its reactivity and compatibility with various reaction conditions make it a valuable tool for chemists in the synthesis of complex organic molecules.
Used in Chemical Research:
In the realm of chemical research, 2,3,5-Trifluoropyridine-4-carboxaldehyde is employed as a reagent to explore new reaction pathways, mechanisms, and the synthesis of novel compounds. Its unique structure and properties provide researchers with opportunities to investigate its potential applications and interactions with other chemical entities.

Upstream product

• 100202-73-1 4-hydroxymethyl-2,3,5-trifluoropyridine 
• 16297-09-9 2,3,5,6-tetrafluoropyridine-4-carboxaldehyde 
• 24191-31-9 2,3,5,6-tetrafluoro-4-(1-hydroxymethyl)pyridine 
• 16297-07-7 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile 
• 100202-71-9 6-hydrazinopyridine-4-carbinol 

Relevant articles and documents

Synthesis of difluorinated pyridinecarboxaldehyde via electrophilic fluorination

An efficient synthesis of novel 3,5-difluoropyridine-4-carboxaldehyde using N-fluoro-benzenesulfonimide (NSFi) is described. Difluorination was achieved through the reaction of 3,5-dihalo-1,3-dioxolane pyridine with n-butyllithium followed by N-fluorobenzenesulfonimide at -120 °C in good to high yields. Maintaining the low temperature during the transmetallation was found to be critical for the selective formation of the difluoro-susbstitution over the monofluoro one.

Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors

New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2-4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with K(i) values of μM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities. (C) 2000 Elsevier Science Ltd. All rights reserved.