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CAS

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163217-70-7

P-HYDROXY ATORVASTATIN LACTONE is a metabolite of Atorvastatin, which is a selective, competitive HMG-CoA reductase inhibitor. It is a pale-yellow to tan solid and plays a significant role in the treatment of hypercholesterolemia.

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  • 5-(4-fluorophenyl)-1-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-n-(4-hydroxyphenyl)-4-phenyl-2-propan-2-ylpyrrole-3-carboxamide

    Cas No: 163217-70-7

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  • 163217-70-7 Structure

  • Basic information

    1. Product Name: P-HYDROXY ATORVASTATIN LACTONE
    2. Synonyms: P-HYDROXY ATORVASTATIN LACTONE;5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide;5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N-(4-hydroxyphenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxaMide;4-Hydroxy Atorvastatin Lactone (EP);Atorvastatin 4-Hydroxy Lactone;5-(4-Fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)-ethyl)-N-(4-hydroxyp
    3. CAS NO:163217-70-7
    4. Molecular Formula: C33H33FN2O5
    5. Molecular Weight: 556.62
    6. EINECS: N/A
    7. Product Categories: Various Metabolites and Impurities;Metabolites
    8. Mol File: 163217-70-7.mol

  • Chemical Properties

    1. Melting Point: 103-106°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: N/A
    9. CAS DataBase Reference: P-HYDROXY ATORVASTATIN LACTONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: P-HYDROXY ATORVASTATIN LACTONE(163217-70-7)
    11. EPA Substance Registry System: P-HYDROXY ATORVASTATIN LACTONE(163217-70-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 163217-70-7(Hazardous Substances Data)

163217-70-7 Usage

Uses

Used in Pharmaceutical Industry:
P-HYDROXY ATORVASTATIN LACTONE is used as a therapeutic agent for the treatment of hypercholesterolemia. It functions by lowering elevated levels of LDL-cholesterol and triglycerides in patients, thus helping to manage and reduce the risk of cardiovascular diseases.
Used in Research and Development:
As a metabolite of Atorvastatin, P-HYDROXY ATORVASTATIN LACTONE is also used in research and development for further understanding the mechanisms of action, pharmacokinetics, and potential applications in the treatment of other related conditions. This can lead to the development of new drugs or improved drug formulations with enhanced efficacy and safety profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 163217-70-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,2,1 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 163217-70:
(8*1)+(7*6)+(6*3)+(5*2)+(4*1)+(3*7)+(2*7)+(1*0)=117
117 % 10 = 7
So 163217-70-7 is a valid CAS Registry Number.

163217-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(4-hydroxyphenyl)-4-phenyl-2-propan-2-ylpyrrole-3-carboxamide

1.2 Other means of identification

Product number -
Other names 5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:163217-70-7 SDS

163217-70-7Downstream Products

163217-70-7Relevant articles and documents

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed

, p. 261 - 270 (2007/10/03)

D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.

[(Hydroxyphenylamino) carbonyl] pyrroles

-

, (2008/06/13)

2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(hydroxyphenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, and their lactone forms, and salts and solyates thereof, inhibit cholesterol biosynthesis, and thus are useful in treating hyperchole

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