- SUBSTITUTED HETEROCYCLIC INHIBITORS OF PTPN11
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The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
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Paragraph 0223-0224
(2019/11/19)
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- HETEROCYCLIC INHIBITORS OF PTPN11
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The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
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Paragraph 0312; 0313
(2018/01/04)
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- 2-CYANOPYRROLIDINECARBOXAMIDE COMPOUND
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A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is =CH2, =CHF or =CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.
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Page/Page column 65
(2008/06/13)
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- 1-HALOPYRIDIN-4-AMINO-4-ALKYLPIPERIDINES
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The present invention relates to novel heteroarylpiperidines of formula (I): STR1 in which Hal is a halogen atom, Alk is a C 1-C. sub.4 alkyl group and X, Y and Z are each--CH= and their salts, to a process for their preparation and to their use as drugs active as 5-HT. sub.3 agonists.
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