1637635-81-4

Basic information

• Product Name: (R)-4-FLUORO-INDAN-1-YLAMINE
• Synonyms: (R)-4-FLUORO-INDAN-1-YLAMINE
• CAS NO: 1637635-81-4
• Molecular Formula: C9H10FN
• Molecular Weight: 151.18
• Mol File: 1637635-81-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-4-FLUORO-INDAN-1-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-FLUORO-INDAN-1-YLAMINE(1637635-81-4)
• EPA Substance Registry System: (R)-4-FLUORO-INDAN-1-YLAMINE(1637635-81-4)

Safety Data

• Hazardous Substances Data: 1637635-81-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Compounds Synthesis:
(R)-4-FLUORO-INDAN-1-YLAMINE is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structural features and chiral nature.
Used in Drug Development:
(R)-4-FLUORO-INDAN-1-YLAMINE is used as a research tool in medicinal chemistry, contributing to the development of new drugs with potential therapeutic applications.
Used in Treatment of Neurological and Psychiatric Disorders:
(R)-4-FLUORO-INDAN-1-YLAMINE is used as a compound with potential therapeutic applications in the treatment of various neurological and psychiatric disorders, as studies have shown it exhibits activity at certain receptors.
Used in Receptor Research:
(R)-4-FLUORO-INDAN-1-YLAMINE is used as a research compound to study the activity and interaction with specific receptors, which can lead to a better understanding of their role in neurological and psychiatric disorders and the development of targeted therapies.

Upstream product

• 148960-34-3 1-fluoro-benzocyclopentyl-5-amine 
• 73045-31-5 4-Fluorindanon-1-oxim 
• 699-99-0 4-fluoro-1-indanone 

Downstream Products

• 1637635-81-4 4-fluoro-1R-aminoindane 

Relevant articles and documents

NOVEL COMPOUNDS

The invention relates to compounds of formula (I) and related aspects.

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

A library of 132 racemic chiral amines (α-substituted methylbenzylamines, benzhydrylamines, 1,2,3,4-tetrahydronaphthylamines (THNs), indanylamines, allylic and homoallylic amines, propargyl amines) was screened against the most versatile monoamine oxidase (MAO-N) variants D5, D9 and D11. MAO-N D9 exhibited the highest activity for most substrates and was applied to the deracemisation of a comprehensive set of selected primary amines. In all cases, excellent enantioselectivity was achieved (e.e. >99%) with moderate to good yields (55–80%). Conditions for the deracemisation of primary amines using a MAO-N/borane system were further optimised using THN as a template addressing substrate load, nature of the enzyme preparation, buffer systems, borane sources, and organic co-solvents.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

Monofluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase

N-propargyl-1-amonoindan monofluorinated in the phenyl ring and their use as selective inhibitors of monoamine oxidase (MAO). There are provided several processes for the preparation of these novel compounds. There are also provided as novel compounds