Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene
2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp2)-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.
SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION
The invention relates to substituted cyclohexyl-1,4-diamine derivatives, to a method for their production, to medicaments containing said compounds and to the use of substituted cyclohexyl-1,4-diamine derivatives for producing medicaments.
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Page/Page column 25
(2008/06/13)
Kinetic resolution of α-acetoxy N-acyl oxazolidinethiones by a chiral O-nucleophilic acyl transfer catalyst
The kinetic resolution of α-acetoxy N-acyl oxazolidinethiones using the chiral, nonracemic O-nucleophilic acyl transfer catalyst 8 is described. The reaction proceeds on a variety of substrates in excellent yields, with s-factors ranging from 17 to 31. Copyright
Nolle, Gregory T.,Sammakia, Tarek,Steel, Peter J.
p. 13502 - 13503
(2007/10/03)
A facile synthesis of enantiopure γ-amino- and γ-hydroxy-β- ketosulfones
Enantiopure γ-amino and γ-hydroxy-β-ketosulfones have been synthesized in high yields from α-diazoketones derived from the α-amino and αhydroxy acid chiral pools.
Asymmetric induction in the cycloaddition of a mandeloylnitroso compound and penta-1,3-diene: X-ray crystal structure analysis of two N-mandeloyldihydrooxazines
Oxidation of (+/-)-mandelohydroxamic acid with tetraethylammonium periodate in the presence of (E)-penta-1,3-diene at 0 deg C gave a mixture of 4 racemic cycloadducts of the derived, transient acylnitroso compound (+/-)-2.The 6-methyl 5 and 6 and 3-methyl 7 and 8 pairs of diastereoisomeric dihydro-oxazines were obtained in the ratio 3.0 : 1 : 1.2 :1.2 , respectively.The relative configurations of the racemic cycloadducts 5 and 7 were determined by X-ray crystallography.The relative asymmetric inductions observed for the pairs of regioisomers 5 and 6 and 7 and 8 are briefly discussed.
Freer, Andrew A.,Isaacs, Neil W.,Kirby, Gordon W.,Snedden, Peter,Tierney, Sean G. T.
p. 601 - 621
(2007/10/03)
Synthesis of Chiral α-Aryl-α-Hydroxyacetic Acids: Substituent Effects in Pig Liver Acetone Powder (PLAP) Induced Enantioselective Hydrolysis
Pig liver acetone powder (PLAP) catalyzed hydrolysis of alkyl α-acetoxy-α-arylacetates produces alkyl (S)-α-aryl-α-hydroxyacetates in 23-80percent enantiomeric purities.Enantioselectivity is dependent on the ester group of O-acetylmandelates.Substitution on the aromatic ring results in inferior selectivities.Only acetate group is hydrolyzed by PLAP while the ester functionality is found to be completely intact.
Basavaiah, Deevi,Krishna, Peddinti Rama
p. 2403 - 2416
(2007/10/02)
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