1638-63-7

Basic information

• Product Name: 2-Acetoxy-2-phenylacetyl chloride
• Synonyms: Benzeneacetyl chloride, alpha-(acetyloxy)-;O-Acetylmandelicacidchoride;LABOTEST-BB LTBB000504;DL-MANDELOYL CHLORIDE ACETATE;1-(Chloroformyl)benzyl acetate;2-ACETOXY-2-PHENYLACETYL CHLORIDE;ACETYLMANDELIC CHLORIDE;O-ACETYLMANDELIC ACID CHLORIDE
• CAS NO: 1638-63-7
• Molecular Formula: C₁₀H₉ClO₃
• Molecular Weight: 212.63
• EINECS: 216-674-6
• Mol File: 1638-63-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 36°C
• Boiling Point: 125-130 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colourless to slightly yellow liquid
• Density: 0.943 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0122mmHg at 25°C
• Refractive Index: n20/D 1.514(lit.)
• Storage Temp.: 0-6°C
• CAS DataBase Reference: 2-Acetoxy-2-phenylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetoxy-2-phenylacetyl chloride(1638-63-7)
• EPA Substance Registry System: 2-Acetoxy-2-phenylacetyl chloride(1638-63-7)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1638-63-7(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

InChI:InChI=1/C10H9ClO3/c1-7(12)14-9(10(11)13)8-5-3-2-4-6-8/h2-6,9H,1H3/t9-/m0/s1

Upstream product

• 611-71-2 MANDELIC ACID 
• 75-36-5 acetyl chloride 
• 10026-13-8 phosphorus pentachloride 
• 29071-09-8 2-acetoxy-2-phenylacetic acid 

Downstream Products

• 101351-43-3 N-(4-nitro-phenacyl)-mandelamide 
• 54755-95-2 2-oxo-1-phenyl-2-(phenylamino)ethyl acetate 
• 92192-54-6 DL-2-Diazo-3-oxo-4-acetoxy-4-phenyl-buttersaeure-aethylester 
• 94258-75-0 2-acetoxy-2-phenyl-N-(4-phenyl-thiazol-2-yl)-acetamide 
• 31956-78-2 triphenylethenol 
• 131635-47-7 acetoxy-phenyl-pyruvonitrile 
• 868532-34-7 acetic acid 2-oxo-1-phenyl-2-(2-thioxo-oxazolidin-3-yl)-ethyl ester 
• 66367-01-9 3-ethyl-6-phenyl-1H,6H-pyrrolo[1,2,3-de]quinoxaline-2,5-dione 
• 184484-04-6 3-(trimethylgermyl)-2-propynyl ester of (α-acetoxy)phenylacetic acid 
• 184484-05-7 3-(triethylgermyl)-2-propynyl ester of (α-acetoxy)phenylacetic acid 
• 182342-84-3 Acetoxy-phenyl-acetic acid prop-2-ynyl ester 

Relevant articles and documents

Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene

2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp2)-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.

SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION

The invention relates to substituted cyclohexyl-1,4-diamine derivatives, to a method for their production, to medicaments containing said compounds and to the use of substituted cyclohexyl-1,4-diamine derivatives for producing medicaments.

Asymmetric induction in the cycloaddition of a mandeloylnitroso compound and penta-1,3-diene: X-ray crystal structure analysis of two N-mandeloyldihydrooxazines

Oxidation of (+/-)-mandelohydroxamic acid with tetraethylammonium periodate in the presence of (E)-penta-1,3-diene at 0 deg C gave a mixture of 4 racemic cycloadducts of the derived, transient acylnitroso compound (+/-)-2.The 6-methyl 5 and 6 and 3-methyl 7 and 8 pairs of diastereoisomeric dihydro-oxazines were obtained in the ratio 3.0 : 1 : 1.2 :1.2 , respectively.The relative configurations of the racemic cycloadducts 5 and 7 were determined by X-ray crystallography.The relative asymmetric inductions observed for the pairs of regioisomers 5 and 6 and 7 and 8 are briefly discussed.