1638-63-7

Usage

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

InChI:InChI=1/C10H9ClO3/c1-7(12)14-9(10(11)13)8-5-3-2-4-6-8/h2-6,9H,1H3/t9-/m0/s1

Upstream product

• 29071-09-8 2-acetoxy-2-phenylacetic acid 
• 611-71-2 MANDELIC ACID 
• 75-36-5 acetyl chloride 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 17173-38-5 1-acetoxy-3-diazo-1-phenyl-acetone 
• 408523-52-4 1-acetoxy-3-chloro-1-phenyl-2-propanone 
• 56485-04-2 benzylglyoxal 
• 100-52-7 benzaldehyde 
• 140220-88-8 1-(acetoxy-phenyl-acetyl)-piperidine 
• 1020-17-3 1-phenyl-2-[4]pyridylamino-ethanol 
• 119154-01-7 N²-D-mandeloyl-L-asparagine 
• 10385-32-7 3-acetyl-5-phenyl-furan-2,4-dione 
• 119154-01-7 N²-L-mandeloyl-L-asparagine 
• 54755-95-2 2-oxo-1-phenyl-2-(phenylamino)ethyl acetate 
• 101730-04-5 acetoxy-phenyl-acetic acid-(benzyl-methyl-amide) 
• 872808-76-9 N-mandeloyl-alanine 
• 110530-75-1 acetoxy-phenyl-acetic acid-[benzyl-(2-dimethylamino-ethyl)-amide] 

Relevant academic research and scientific papers

Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene

2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp2)-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.

Kinetic resolution of α-acetoxy N-acyl oxazolidinethiones by a chiral O-nucleophilic acyl transfer catalyst

The kinetic resolution of α-acetoxy N-acyl oxazolidinethiones using the chiral, nonracemic O-nucleophilic acyl transfer catalyst 8 is described. The reaction proceeds on a variety of substrates in excellent yields, with s-factors ranging from 17 to 31. Copyright

SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION

The invention relates to substituted cyclohexyl-1,4-diamine derivatives, to a method for their production, to medicaments containing said compounds and to the use of substituted cyclohexyl-1,4-diamine derivatives for producing medicaments.

A facile synthesis of enantiopure γ-amino- and γ-hydroxy-β- ketosulfones

Enantiopure γ-amino and γ-hydroxy-β-ketosulfones have been synthesized in high yields from α-diazoketones derived from the α-amino and αhydroxy acid chiral pools.

Asymmetric induction in the cycloaddition of a mandeloylnitroso compound and penta-1,3-diene: X-ray crystal structure analysis of two N-mandeloyldihydrooxazines

Oxidation of (+/-)-mandelohydroxamic acid with tetraethylammonium periodate in the presence of (E)-penta-1,3-diene at 0 deg C gave a mixture of 4 racemic cycloadducts of the derived, transient acylnitroso compound (+/-)-2.The 6-methyl 5 and 6 and 3-methyl 7 and 8 pairs of diastereoisomeric dihydro-oxazines were obtained in the ratio 3.0 : 1 : 1.2 :1.2 , respectively.The relative configurations of the racemic cycloadducts 5 and 7 were determined by X-ray crystallography.The relative asymmetric inductions observed for the pairs of regioisomers 5 and 6 and 7 and 8 are briefly discussed.

Synthesis of Chiral α-Aryl-α-Hydroxyacetic Acids: Substituent Effects in Pig Liver Acetone Powder (PLAP) Induced Enantioselective Hydrolysis

Pig liver acetone powder (PLAP) catalyzed hydrolysis of alkyl α-acetoxy-α-arylacetates produces alkyl (S)-α-aryl-α-hydroxyacetates in 23-80percent enantiomeric purities.Enantioselectivity is dependent on the ester group of O-acetylmandelates.Substitution on the aromatic ring results in inferior selectivities.Only acetate group is hydrolyzed by PLAP while the ester functionality is found to be completely intact.