163808-09-1

Basic information

• Product Name: 4-AMINOBENZOOXAZOL
• Synonyms: 4-AMINOBENZOOXAZOL ;Benzooxazol-4-ylamine;4-BenzoxazolaMine;Benzo[d]oxazol-4-aMine;1,3-Benzoxazol-4-amine, 4-Aminobenzo[d]oxazole;4-Aminobenzooxazole;4-Aminobenzoxazole
• CAS NO: 163808-09-1
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.13534
• Mol File: 163808-09-1.mol

Chemical Properties

• Melting Point: 77-79°
• Boiling Point: 282.296 °C at 760 mmHg
• Flash Point: 124.528 °C
• Appearance: /
• Density: 1.317 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.16±0.30(Predicted)
• CAS DataBase Reference: 4-AMINOBENZOOXAZOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOBENZOOXAZOL(163808-09-1)
• EPA Substance Registry System: 4-AMINOBENZOOXAZOL(163808-09-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 163808-09-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Aminobenzooxazol is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of new medicinal compounds with potential therapeutic effects.
Used in Dye and Pigment Production:
In the field of materials science, 4-ABO is utilized in the production of fluorescent dyes and pigments. Its chemical properties make it suitable for creating vibrant and stable colorants used in various applications, including textiles, plastics, and paints.
Used as a Reagent in Organic Synthesis:
4-Aminobenzooxazol serves as a valuable reagent in organic synthesis, particularly in the creation of heterocyclic compounds. Its ability to form diverse chemical structures makes it an essential component in the synthesis of complex organic molecules.
Used in Agricultural Chemicals:
4-Aminobenzooxazol finds applications in agriculture, where it is used in the development of agrochemicals. Its role in creating effective and targeted pesticides or other agricultural products contributes to enhanced crop protection and yield.
Used in Research for Pharmacological Properties:
4-ABO has been studied for its potential pharmacological properties, such as anticonvulsant and neuroprotective effects. Researchers are exploring its therapeutic potential in treating various neurological disorders and conditions.
Safety Considerations:
It is crucial to handle 4-Aminobenzooxazol with care due to its potential hazards if not properly managed. Adequate safety measures should be taken during its production, use, and disposal to minimize risks to human health and the environment.

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 163808-13-7 4-nitrobenzo[d]oxazole 

Downstream Products

• 1380314-65-7 3-tosyl-7-hydroxybenzimidazole 
• 478553-46-7 C₁₄H₁₂N₂O₄S 
• 1380314-28-2 C₁₄H₁₂N₂O₃S 
• 1380314-29-3 C₁₄H₉F₃N₂O₃S 
• 1380314-32-8 C₁₇H₁₈N₂O₃S 
• 163808-08-0 4-hydroxy-1-methyl-1H-benzimidazole 
• 959246-43-6 tert-butyl benzo[d]oxazole-4-ylcarbamate 
• 1223569-58-1 (E)-N-benzoxazol-4-yl-3-(3-acetoxy-4-methoxyphenyl)prop-2-enamide 

Relevant articles and documents

COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF

PROBLEM TO BE SOLVED: To provide a compound having a ZNF143 inhibitory activity as well as to provide a ZNF143 inhibitory agent and pharmaceutical composition containing the same. SOLUTION: Provided is a compound represented by formula (I) or a salt thereof as well as a ZNF143 inhibitory agent containing the same and a pharmaceutical composition having the same as an active ingredient. A-B-C-D (I)[A is H, a methyl group, a naphthyl group, a phenyl group or a nitrogen-containing heterocyclic ring; B is as shown below, and C is an amide bond or a heteroaromatic ring containing N and O; D is a substituted/unsubstituted phenyl group or a monocyclic heteroaromatic ring containing N or S; and C and D are both fused heterocyclic ring or the like optionally having a substituent group.]. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

Investigating chelating sulfonamides and their use in metalloproteinase inhibitors

Matrix metalloproteinase inhibitors (MMPi) utilize zinc-binding groups (ZBGs) to chelate the catalytic Zn(ii) ion resulting in enzyme inhibition. Adapting findings from the literature of Zn(ii) ion sensors, we previously reported chelating sulfonamide inh

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

SYNTHESIS OF 4-HYDROXY-1-METHYLBENZIMIDAZOLE AND 7-HYDROXY-1-METHYLBENZIMIDAZOLE

4-Hydroxy-1-methylbenzimidazole (1) was synthesized via condensation of 2-amino-3-nitrophenol (3) with trimethyl orthoformate, reduction of the resulting 4-nitrobenzoxazole (4) to amine (5), reaction with hydroxymethylbenzotriazole to form benzotriazolyl adduct (6), reduction to give 4-methylaminobenzoxazole (7), and finally base catalyzed rearrangement.The synthesis of 7-hydroxy-1-methylbenzimidazole (2) was accomplished by reduction of 4 with sodium borohydride to form 3-nitro-2-methylaminophenol (8), followed by hydrogenation to give amino derivative (9) and condensation with trimethyl orthoformate.