603-85-0

Basic information

• Product Name: 2-Amino-3-nitrophenol
• Synonyms: 2-Amino-3-nitrophenol,98%;2-Amino-3-nitrophenol,2-Hydroxy-6-nitroaniline;2-AMino-3-nitrophenol, 98% 5GR;2-Hydroxy-6-nitroaniline, 2-Amino-3-hydroxynitrobenzene;2-Amino-3-nitrophenol 98%;2-AMINO-3-NITROPHENOL;2-AMINO-3-HYDROXYNITROBENZENE;2-HYDROXY-6-NITROANILINE
• CAS NO: 603-85-0
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• EINECS: 210-060-1
• Product Categories: Alcohols and Derivatives;Amines and Anilines;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;API intermediates
• Mol File: 603-85-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 212-213 °C(lit.)
• Boiling Point: 322.46°C (rough estimate)
• Flash Point: 144.829 °C
• Appearance: brown-red/Powder
• Density: 1.3617 (estimate)
• Refractive Index: 1.6890 (rough estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.23±0.25(Predicted)
• BRN: 2804307
• CAS DataBase Reference: 2-Amino-3-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-nitrophenol(603-85-0)
• EPA Substance Registry System: 2-Amino-3-nitrophenol(603-85-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 603-85-0(Hazardous Substances Data)

Usage

Chemical Properties

Red-brown powder

Uses

2-Amino-3-nitrophenol has been used:as semipermanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye productsas matrix during visible matrix-assisted laser desorption/ionization (VIS-MALDI) mass spectrometryin preparation of 1,3-benzoxazole-4,7-dione

InChI:InChI=1/C6H6N2O3/c7-6-4(8(10)11)2-1-3-5(6)9/h1-3,9H,7H2

Upstream product

• 7664-93-9 sulfuric acid 
• 5467-64-1 2-acetamidophenyl acetate 
• 163808-13-7 4-nitrobenzo[d]oxazole 
• 66-56-8 2,3-dinitrophenol 
• 69194-51-0 1-acetoxy-2-acetylamino-3-nitro-benzene 

Downstream Products

• 59649-56-8 2,3-diaminophenol 
• 197243-48-4 2-iodo-3-nitrophenol 
• 478553-83-2 2-methyl-4-nitrobenzo[d]oxazole 
• 69194-51-0 1-acetoxy-2-acetylamino-3-nitro-benzene 
• 59820-29-0 2-acetylamino 3-nitro phenol 
• 876496-59-2 chloro-acetic acid-(2-hydroxy-6-nitro-anilide) 
• 858013-76-0 toluene-4-sulfonic acid-(2-amino-3-nitro-phenyl ester) 
• 101495-34-5 4-nitro-3H-benzooxazole-2-thione 
• 132059-11-1 R-<1-(2-amino-3-nitrophenoxy)>-2',3'-epoxypropane 
• 132059-13-3 S-<1-(2-amino-3-nitrophenoxy)>-2',3'-epoxypropane 
• 132059-12-2 R-<1-(2-amino-3-nitrophenoxy)>-3'-(N-t-butylamino)propan-2'-ol 
• 143708-26-3 2-(chloromethyl)-4-nitrobenzoxazole 
• 148726-33-4 2-<3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy>-6-nitroaniline 
• 101935-40-4 2-bromo-3-hydroxy-1-nitrobenzene 

Relevant articles and documents

SYNTHESIS OF 4-HYDROXY-1-METHYLBENZIMIDAZOLE AND 7-HYDROXY-1-METHYLBENZIMIDAZOLE

4-Hydroxy-1-methylbenzimidazole (1) was synthesized via condensation of 2-amino-3-nitrophenol (3) with trimethyl orthoformate, reduction of the resulting 4-nitrobenzoxazole (4) to amine (5), reaction with hydroxymethylbenzotriazole to form benzotriazolyl adduct (6), reduction to give 4-methylaminobenzoxazole (7), and finally base catalyzed rearrangement.The synthesis of 7-hydroxy-1-methylbenzimidazole (2) was accomplished by reduction of 4 with sodium borohydride to form 3-nitro-2-methylaminophenol (8), followed by hydrogenation to give amino derivative (9) and condensation with trimethyl orthoformate.