16383-57-6Relevant articles and documents
β-Stereoselective phosphorylations applied to the synthesis of ADP- and polyprenyl-β-mannopyranosides
Li, Tianlei,Tikad, Abdellatif,Pan, Weidong,Vincent, Stphane P.
, p. 5628 - 5631 (2014)
An efficient and convenient synthetic route to glycosyl 1-β-phosphates has been developed using diallyl chlorophosphate as a phosphorylating agent with 4-N,N-dimethylaminopyridine under mild conditions. Diallyl-glycosyl 1-β-phosphate triesters of d-manno, l-glycero-d-manno-hepto-, d-gluco-, d-galacto-, and l-fuco-pyranose as well as lactose have been obtained by this strategy in good yields and excellent β-selectivities. Furthermore, the diallyl 6-azido-mannosyl 1-β-phosphate 2 was deprotected under mild conditions and converted into potentially clickable analogues of β-mannosyl phosphoisoprenoids I and ADP-heptose II.
A General Strategy to Synthesize ADP-7-Azido-heptose and ADP-Azido-mannoses and Their Heptosyltransferase Binding Properties
Li, Tianlei,Tikad, Abdellatif,Fu, Huixiao,Milicaj, Jozafina,Castro, Colleen D.,Lacritick, Marine,Pan, Weidong,Taylor, Erika A.,Vincent, Stphan P.
, p. 1638 - 1642 (2021)
The multistep synthesis of a novel ADP-7-azido-7-deoxy-l-glycero-β-d-manno-heptopyranoside 2a and several analogues as heptosyltransferase ligands is described. The synthesis of the key intermediate heptoside-1-β-phosphate 3a involved a β-stereoselective
PHOSPHOLIPID ETHER CONJUGATES AS CANCER-TARGETING DRUG VEHICLES
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Paragraph 000163, (2021/03/19)
Disclosed herein are therapeutic compounds capable of targeting a broad range of tumor cells. The present disclosure is further directed to compositions comprising the therapeutic compounds, methods of manufacturing the therapeutic compounds, and methods of treating cancer comprising administering the therapeutic compounds.
Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
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Paragraph 0336-0337, (2020/02/19)
Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
Curcumin phosphate compound, preparation method and uses thereof
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Paragraph 0096; 0097; 0098, (2016/10/08)
The present invention relates to a curcumin phosphate compound, a preparation method and uses thereof, and belongs to the field of pharmaceutical chemistry, wherein the structural general formula of the compound is defined in the specification, X is O or
A GENERAL APPROACH TO NUCLEOSIDE 3'- AND 5'-MONOPHOSPHATES
Hayakawa, Y.,Wakabayashi, S.,Nobori, T.,Noyori, R.
, p. 2259 - 2262 (2007/10/02)
Diallyloxyphosphorylation of nucleoside hydroxyls followed by palladium(0)-catalyzed deallylation provides a new, general method for the preparation of the 3'- and 5'-monophosphates.
Substituted polyhalogenated cyclopentadienes
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, (2008/06/13)
Compounds of the formula SPC1 Wherein Y is independently selected from the group consisting of methyl, hydrogen and a halogen of atomic weight between 35 and 80 with at least four of the Y substituents being said halogen; each R is independently selected from the group consisting of alkyl having at least one and a maximum of 12 carbon atoms, alkenyl having at least 2 and a maximum of 5 carbon atoms, alkoxyalkyl having at least 2 and a maximum of 6 carbon atoms and cycloalkyl having at least 5 and a maximum of 6 carbon atoms, and n is one of the integers one or two. These compounds possess insecticidal activity and are valuable intermediates for the preparation of insecticides having low mammalian toxicity.
